Projects per year
Personal profile
Research interests
Pediatric critical care in low resource settings
Over the past 20 years I have performed research concerning several topics affecting care of critically ill children in low resource settings. Subtopics include
1. Technical advances to timely identify critically ill children. Over the past 3 years this has been my major topic of research. Most recent success is that I secured a large EU grant (3.4 million euro) as the PI on the IMPALA project. This project, performed by 7 international institutes, is aimed at developing an innovative vital signs monitor to timley identify deterioration of critically ill children. The monitor applies several innovative techniques including new sensors, artificial intelligence and robust and simple hard and software sollutions. The model builds on pilot data from 3 studies I recently performed in Malawi and are currently being analysed by my team consiting of Dutch PhD student (R Assies), a Malawian MMED student and several Dutch Master students.
2. Circulatory failure & Severe anaemia: Based on my initial PhD thesis (distinction) I supervised a PhD project concerning severe anaemia (F Jonker). In preparation of the above described project aimed at develpment of an innovative patient monitor for low income countries we performed several studies concerning new markers (CRI and HRV) and new prediction models to indentify children with shock.
3. Severe infectious diseases: as a spin off of my own PhD, and prior to focussing on ICU related topics, I supervised 4 PhD students (Sigaloff, Boender, Boerma, Huibers) in the field of HIV care and studied severe infections in African children.
specialisation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Projects
- 1 Active
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Boele van Hensbroek M.: Programmes
Boele van Hensbroek, M., van Woensel, J., Calis, J., Voskuijl, W., Aderibigbe, S., Bartels, R., Boerma, R., Huibers, M., Jupimai, T., Kiemde, F., Moons, P., Brals, D. & Trip, M.
1/12/2011 → …
Project: Research
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Severe anaemia complicating HIV in Malawi; Multiple co-existing aetiologies are associated with high mortality
Huibers, M. H. W., Bates, I., McKew, S., Allain, T. J., Coupland, S. E., Phiri, C., Phiri, K. S., van Hensbroek, M. B. & Calis, J. C., 2020, In: PLOS ONE. 15, 2, e0218695.Research output: Contribution to journal › Article › Academic › peer-review
Open Access9 Citations (Scopus) -
Alarming increase in pretreatment HIV drug resistance in children living in sub-Saharan Africa: A systematic review and meta-analysis
Boerma, R. S., Sigaloff, K. C. E., Akanmu, A. S., Inzaule, S., van Hensbroek, M. B., de Wit, T. F. R. & Calis, J. C., 1 Jan 2017, In: Journal of antimicrobial chemotherapy. 72, 2, p. 365-371 7 p.Research output: Contribution to journal › Article › Academic › peer-review
64 Citations (Scopus) -
HIV-1-resistance-associated mutations after failure of first-line antiretroviral treatment among children in resource-poor regions: a systematic review
Sigaloff, K. C. E., Calis, J. C. J., Geelen, S. P., van Vugt, M. & de Wit, T. F. R., 2011, In: Lancet infectious diseases. 11, 10, p. 769-779Research output: Contribution to journal › Review article › Academic › peer-review
86 Citations (Scopus) -
Severe sepsis and septic shock
Calis, J., van Woensel, J. & Lemson, J., 2013, In: New England journal of medicine. 369, 21, p. 2062Research output: Contribution to journal › Comment/Letter to the editor › Academic
8 Citations (Scopus) -
Severe anemia in Malawian children
Calis, J. C., Phiri, K. S., Faragher, E. B., Brabin, B. J., Bates, I., Cuevas, L. E., de Haan, R. J., Phiri, A. I., Malange, P., Khoka, M., Hulshof, P. J., van Lieshout, L., Beld, M. G., teo, Y. Y., Rockett, K. A., Richardson, A., Kwiatkowski, D. P., Molyneux, M. E. & van Hensbroek, M. B., 2016, In: Malawi Medical Journal. 28, 3, p. 99-107Research output: Contribution to journal › Article › Academic › peer-review
170 Citations (Scopus)