Project Details
Description
This line of research focuses on the significance of variations in the filaggrin gene (FLG) for the skin barrier and the development and prognosis of occupational contact eczema. Research has also looked at whether the decomposition products of the filaggrin protein can be used as a phenotypic marker for the FLG genotype.
To study the extent to which FLG mutations contribute to the development of occupational contact eczema (CE), a prospective study is being conducted among student nurses. 500 students were included in the study in 2009. In addition to FLG mutations, the exposure of these students to skin-irritating factors during their internships will also be charted. The study will be completed in 2011.
The role of FLG mutations in the prognosis of contact eczema is being studied in collaboration with the University of Osnabruck. As part of an intervention study, started in 2009, 1000 patients with chronic CE are being examined to determine whether FLG mutations influence the prognosis of the disease.
Current projects:
• SIG, 2008-2011:‘’Genetic susceptibility to occupational diseases related to atopy’’ .Project leader
• NWO-STW, 2009-2013. ‘’Development of human reconstructed models as a tool for screening purposes’’ Co-applicant of the project. 400 k€
• EU COST Network (7th Framework): 2009-2013. ‘’Skin barrier and atopic diseases’’. Coordinator and chair. 360 k€
• FES High-Tech Systems & Materials (HTS&M). 2010- . Health Risk of manufactured nanoparticles. Bioavailability of MNPs. In vivo penetration of MNPs across skin barrier Project leader of the WP.
To study the extent to which FLG mutations contribute to the development of occupational contact eczema (CE), a prospective study is being conducted among student nurses. 500 students were included in the study in 2009. In addition to FLG mutations, the exposure of these students to skin-irritating factors during their internships will also be charted. The study will be completed in 2011.
The role of FLG mutations in the prognosis of contact eczema is being studied in collaboration with the University of Osnabruck. As part of an intervention study, started in 2009, 1000 patients with chronic CE are being examined to determine whether FLG mutations influence the prognosis of the disease.
Current projects:
• SIG, 2008-2011:‘’Genetic susceptibility to occupational diseases related to atopy’’ .Project leader
• NWO-STW, 2009-2013. ‘’Development of human reconstructed models as a tool for screening purposes’’ Co-applicant of the project. 400 k€
• EU COST Network (7th Framework): 2009-2013. ‘’Skin barrier and atopic diseases’’. Coordinator and chair. 360 k€
• FES High-Tech Systems & Materials (HTS&M). 2010- . Health Risk of manufactured nanoparticles. Bioavailability of MNPs. In vivo penetration of MNPs across skin barrier Project leader of the WP.
| Status | Active |
|---|---|
| Effective start/end date | 1/07/2007 → … |