Posttraumatic stress disorder and the microbiome

Posttraumatic Stress Disorder, or PTSD, is a significant health challenge affecting an extensive demographic worldwide. It doesn't merely inconvenience—it noticeably diminishes one's overall well-being and quality of life. Despite the availability of various treatments, their effectiveness varies widely, underlining the necessity to understand the mechanisms behind the disorder. An emerging area of exploration is the influence of the human microbiome, the full complement of microbes within us, on PTSD. Several studies have correlated microbiome imbalances or dysbiosis with mental health disorders, implying potential implications for PTSD via the gut-brain axis, a two-way communication system between our brain and gut. Still, the precise dynamics of this interaction and the extent of its therapeutic potential remain not fully elucidated. This project provides a comprehensive look at current research on the microbiome-PTSD interplay, shedding light on potential treatment avenues and areas needing additional exploration. We also analyse the HELIUS-data and performing pre-clinical study on this relationship.