Project Details


Make Sense> Brain Circuits for rTMS-induced Neuroplasticity
In this interdisciplinary project, we will use state-of-the-art neuronavigated brain stimulation, neuroimaging and cognitive models, to improve rTMS efficacy and gain better insights in depressive circuitry involved in rTMS responses.
Goal: Enhanced efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) using cognitive tasks during stimulation.

Methods: In this proof-of-concept study, 10 patients suffering from therapy resistant depression (TRD) will be treated with rTMS. All patients will undergo 10 sessions of stimulation with a standard MDD 10 Hz protocol. The region of interest is the left dorsolateral Pre Frontal Cortex (dlPFC), which will be localized using structural magnetic resonance imaging (MRI) and neuronavigation. During brain stimulation, different networks are activated by performing cognitive tasks. In 5 patients, the cingulo-frontal (CFN) and frontoparietal networks (FPN) - which are hypoactive in depression - are activated by the emotional Stroop task or The Multi-Source Interference Task (MSIT). In the other 5 patients, a task is performed in a neuropsychological domain that is unaffected by depression, e.g. language with the Boston Naming Test (BNT). Pre- and post-treatment functional MRI (fMRI) is used to study changes in emotional network topology. Outcomes are tolerability and feasibility of this hybrid set-up, as well as efficacy of treatment measured by validated psychometrics. rTMS induced neuro-cardiac variability in heartrate will be measured by electrocardiogram during the first stimulation session.

PhD student> Daan Neuteboom
Short titleSENSE
Effective start/end date1/07/2022 → …