α2-3 Sialic acid binding and uptake by human monocyte-derived dendritic cells alters metabolism and cytokine release and initiates tolerizing T cell programming

Joyce Lübbers; RJE Li; Y van Kooyk; M Ambrosini; H. Kalay; Friederike S. Gorki; S.C.M. Bruijns; Ashley Gallagher; Douwe Molenaar; J Van den Bossche; SJ van Vliet

α2-3 Sialic acid binding and uptake by human monocyte-derived dendritic cells alters metabolism and cytokine release and initiates tolerizing T cell programming

Joyce Lübbers, RJE Li, Y van Kooyk, M Ambrosini, H. Kalay, Friederike S. Gorki, S.C.M. Bruijns, Ashley Gallagher, Douwe Molenaar, J Van den Bossche, SJ van Vliet

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Dendritic cells (DCs) are key in the initiation of the adaptive T cell responses to tailor adequate immunity that corresponds to the type of pathogen encountered. Oppositely, DCs control the resolution phase of inflammation and are able to induce tolerance after receiving anti-inflammatory cytokines or upon encounter of self-associated molecular patterns, such as α2-3 linked sialic acid (α2-3sia). Objective: We here investigated whether α2-3sia, that bind immune inhibitory Siglec receptors, would alter signaling and reprogramming of LPS-stimulated human monocyte-derived DCs (moDCs).

Original language	English
Pages (from-to)	1-18
Journal	Immunotherapy Advances
Volume	1
Issue number	1
Publication status	Published - 9 Jun 2021

Access to Document

https://doi.org/10.1093/immadv/ltab012

Cite this

Lübbers, J., Li, RJE., van Kooyk, Y., Ambrosini, M., Kalay, H., Gorki, F. S., Bruijns, S. C. M., Gallagher, A., Molenaar, D., Van den Bossche, J., & van Vliet, SJ. (2021). α2-3 Sialic acid binding and uptake by human monocyte-derived dendritic cells alters metabolism and cytokine release and initiates tolerizing T cell programming. Immunotherapy Advances, 1(1), 1-18. https://doi.org/10.1093/immadv/ltab012

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abstract = "Dendritic cells (DCs) are key in the initiation of the adaptive T cell responses to tailor adequate immunity that corresponds to the type of pathogen encountered. Oppositely, DCs control the resolution phase of inflammation and are able to induce tolerance after receiving anti-inflammatory cytokines or upon encounter of self-associated molecular patterns, such as α2-3 linked sialic acid (α2-3sia). Objective: We here investigated whether α2-3sia, that bind immune inhibitory Siglec receptors, would alter signaling and reprogramming of LPS-stimulated human monocyte-derived DCs (moDCs).",

author = "Joyce L{\"u}bbers and RJE Li and {van Kooyk}, Y and M Ambrosini and H. Kalay and Gorki, {Friederike S.} and S.C.M. Bruijns and Ashley Gallagher and Douwe Molenaar and {Van den Bossche}, J and {van Vliet}, SJ",

year = "2021",

month = jun,

day = "9",

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Lübbers, J, Li, RJE , van Kooyk, Y, Ambrosini, M, Kalay, H, Gorki, FS, Bruijns, SCM, Gallagher, A, Molenaar, D, Van den Bossche, J & van Vliet, SJ 2021, 'α2-3 Sialic acid binding and uptake by human monocyte-derived dendritic cells alters metabolism and cytokine release and initiates tolerizing T cell programming', Immunotherapy Advances, vol. 1, no. 1, pp. 1-18. <https://doi.org/10.1093/immadv/ltab012>

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T1 - α2-3 Sialic acid binding and uptake by human monocyte-derived dendritic cells alters metabolism and cytokine release and initiates tolerizing T cell programming

AU - Lübbers, Joyce

AU - Li, RJE

AU - van Kooyk, Y

AU - Ambrosini, M

AU - Kalay, H.

AU - Gorki, Friederike S.

AU - Bruijns, S.C.M.

AU - Gallagher, Ashley

AU - Molenaar, Douwe

AU - Van den Bossche, J

AU - van Vliet, SJ

PY - 2021/6/9

Y1 - 2021/6/9

N2 - Dendritic cells (DCs) are key in the initiation of the adaptive T cell responses to tailor adequate immunity that corresponds to the type of pathogen encountered. Oppositely, DCs control the resolution phase of inflammation and are able to induce tolerance after receiving anti-inflammatory cytokines or upon encounter of self-associated molecular patterns, such as α2-3 linked sialic acid (α2-3sia). Objective: We here investigated whether α2-3sia, that bind immune inhibitory Siglec receptors, would alter signaling and reprogramming of LPS-stimulated human monocyte-derived DCs (moDCs).

AB - Dendritic cells (DCs) are key in the initiation of the adaptive T cell responses to tailor adequate immunity that corresponds to the type of pathogen encountered. Oppositely, DCs control the resolution phase of inflammation and are able to induce tolerance after receiving anti-inflammatory cytokines or upon encounter of self-associated molecular patterns, such as α2-3 linked sialic acid (α2-3sia). Objective: We here investigated whether α2-3sia, that bind immune inhibitory Siglec receptors, would alter signaling and reprogramming of LPS-stimulated human monocyte-derived DCs (moDCs).

M3 - Article

SN - 2732-4303

VL - 1

SP - 1

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JO - Immunotherapy Advances

JF - Immunotherapy Advances

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