TY - JOUR
T1 - Bendamustine plus rituximab for the treatment of Waldenström Macroglobulinemia
T2 - Patient outcomes and impact of bendamustine dosing
AU - Arulogun, Suzanne O.
AU - Brian, Duncan
AU - Goradia, Harshita
AU - Cooney, Aaron
AU - Menne, Tobias
AU - Koo, RayMun
AU - O'Neill, Aideen T.
AU - Vos, Josephine M. I.
AU - Pratt, Guy
AU - Turner, Deborah
AU - Marshall, Kirsty
AU - Manos, Kate
AU - Anderson, Claire
AU - Gavriatopoulou, Maria
AU - Kyriakou, Charalampia
AU - Kersten, Marie J.
AU - Minnema, Monique C.
AU - Koutoumanou, Eirini
AU - el-Sharkawi, Dima
AU - Linton, Kim
AU - Talaulikar, Dipti
AU - McCarthy, Helen
AU - Bishton, Mark
AU - Follows, George
AU - Wechalekar, Ashutosh
AU - D'Sa, Shirley P.
N1 - Publisher Copyright: © 2023 Wiley Periodicals LLC.
PY - 2023/5
Y1 - 2023/5
N2 - Bendamustine and rituximab (BR) therapy is commonly used in the treatment of Waldenström Macroglobulinemia (WM). The impact dose of Bendamustine dose on response and survival outcomes is not well-established, and the impact of its use in different treatment settings is not clear. We aimed to report response rates and survival outcomes following BR, and clarify the impact of depth of response and bendamustine dose on survival. A total of 250 WM patients treated with BR in the frontline or relapsed settings were included in this multicenter, retrospective cohort analysis. Rates of partial response (PR) or better differed significantly between the frontline and relapsed cohorts (91.4% vs 73.9%, respectively; p < 0.001). Depth of response impacted survival outcomes: two-year predicted PFS rates after achieving CR/VGPR vs PR were 96% versus 82%, respectively (p = 0.002). Total bendamustine dose was predictive of PFS: in the frontline setting, PFS was superior in the group receiving ≥1000 mg/m2 compared with those receiving 800–999 mg/m2 (p = 0.04). In the relapsed cohort, those who received doses of <600 mg/m2 had poorer PFS outcomes compared with those who received ≥600 mg/m2 (p = 0.02). Attaining CR/VGPR following BR results in superior survival, and total bendamustine dose significantly impacts response and survival outcomes, in both frontline and relapsed settings.
AB - Bendamustine and rituximab (BR) therapy is commonly used in the treatment of Waldenström Macroglobulinemia (WM). The impact dose of Bendamustine dose on response and survival outcomes is not well-established, and the impact of its use in different treatment settings is not clear. We aimed to report response rates and survival outcomes following BR, and clarify the impact of depth of response and bendamustine dose on survival. A total of 250 WM patients treated with BR in the frontline or relapsed settings were included in this multicenter, retrospective cohort analysis. Rates of partial response (PR) or better differed significantly between the frontline and relapsed cohorts (91.4% vs 73.9%, respectively; p < 0.001). Depth of response impacted survival outcomes: two-year predicted PFS rates after achieving CR/VGPR vs PR were 96% versus 82%, respectively (p = 0.002). Total bendamustine dose was predictive of PFS: in the frontline setting, PFS was superior in the group receiving ≥1000 mg/m2 compared with those receiving 800–999 mg/m2 (p = 0.04). In the relapsed cohort, those who received doses of <600 mg/m2 had poorer PFS outcomes compared with those who received ≥600 mg/m2 (p = 0.02). Attaining CR/VGPR following BR results in superior survival, and total bendamustine dose significantly impacts response and survival outcomes, in both frontline and relapsed settings.
UR - http://www.scopus.com/inward/record.url?scp=85150808121&partnerID=8YFLogxK
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85150808121&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/36866925
U2 - https://doi.org/10.1002/ajh.26895
DO - https://doi.org/10.1002/ajh.26895
M3 - Article
C2 - 36866925
SN - 0361-8609
VL - 98
SP - 750
EP - 759
JO - American journal of hematology
JF - American journal of hematology
IS - 5
ER -