[11C]flumazenil-PET: De benzodiazepinereceptor in beeld

Y. P. Dijstelbloem; H. Verschoor; A. D. Windhorst; G. Luurtsema; A. A. Lammertsma; E. J F Franssen

[11C]flumazenil-PET: De benzodiazepinereceptor in beeld

Translated title of the contribution: [11C]flumazenil-PET. An image of the benzodiazepine receptor

Y. P. Dijstelbloem, H. Verschoor, A. D. Windhorst, G. Luurtsema, A. A. Lammertsma, E. J F Franssen

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

Abstract

Positron emission tomography (PET) is an imaging technology with clinical applications in diagnostics and pharmacological research. [¹¹C]flumazenil is a PET-radiopharmaceutical suitable for identification of binding sites for benzodiazepines in the brain. [¹¹C]flumazenil is a radiopharmaceutical with a short shelf-life, due to the short physical half-life of the carbon-II isotope (20 minutes). For this reason, a rapid radionuclide production, chemical synthesis, formulation, quality control and release procedure are required. PET using [¹¹C]flumazenil is clinically applied to localise epileptic foci in the brain. In research, it is used to investigate changes in benzodiazepine receptor concentration and drug binding to receptors.

Translated title of the contribution	[11C]flumazenil-PET. An image of the benzodiazepine receptor
Original language	Dutch
Pages (from-to)	416-422
Number of pages	7
Journal	Pharmaceutisch Weekblad
Volume	138
Issue number	12
Publication status	Published - 21 Mar 2003

Keywords

Drug compounding
Emission-computed
Flumazenil
Radioisotopes
Receptors, GABA-A
Tomography

Cite this

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abstract = "Positron emission tomography (PET) is an imaging technology with clinical applications in diagnostics and pharmacological research. [11C]flumazenil is a PET-radiopharmaceutical suitable for identification of binding sites for benzodiazepines in the brain. [11C]flumazenil is a radiopharmaceutical with a short shelf-life, due to the short physical half-life of the carbon-II isotope (20 minutes). For this reason, a rapid radionuclide production, chemical synthesis, formulation, quality control and release procedure are required. PET using [11C]flumazenil is clinically applied to localise epileptic foci in the brain. In research, it is used to investigate changes in benzodiazepine receptor concentration and drug binding to receptors.",

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AU - Dijstelbloem, Y. P.

AU - Verschoor, H.

AU - Windhorst, A. D.

AU - Luurtsema, G.

AU - Lammertsma, A. A.

AU - Franssen, E. J F

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AB - Positron emission tomography (PET) is an imaging technology with clinical applications in diagnostics and pharmacological research. [11C]flumazenil is a PET-radiopharmaceutical suitable for identification of binding sites for benzodiazepines in the brain. [11C]flumazenil is a radiopharmaceutical with a short shelf-life, due to the short physical half-life of the carbon-II isotope (20 minutes). For this reason, a rapid radionuclide production, chemical synthesis, formulation, quality control and release procedure are required. PET using [11C]flumazenil is clinically applied to localise epileptic foci in the brain. In research, it is used to investigate changes in benzodiazepine receptor concentration and drug binding to receptors.

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KW - Emission-computed

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KW - Radioisotopes

KW - Receptors, GABA-A

KW - Tomography

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[11C]flumazenil-PET: De benzodiazepinereceptor in beeld

Abstract

Keywords

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