TY - JOUR
T1 - 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups
AU - Lundberg, Ingrid E.
AU - Tjärnlund, Anna
AU - Bottai, Matteo
AU - Werth, Victoria P.
AU - Pilkington, Clarissa
AU - Visser, Marianne De
AU - Alfredsson, Lars
AU - Amato, Anthony A.
AU - Barohn, Richard J.
AU - Liang, Matthew H.
AU - Singh, Jasvinder A.
AU - Aggarwal, Rohit
AU - Arnardottir, Snjolaug
AU - Chinoy, Hector
AU - Cooper, Robert G.
AU - Dankó, Katalin
AU - Dimachkie, Mazen M.
AU - Feldman, Brian M.
AU - Torre, Ignacio Garcia-De La
AU - Gordon, Patrick
AU - Hayashi, Taichi
AU - Katz, James D.
AU - Kohsaka, Hitoshi
AU - Lachenbruch, Peter A.
AU - Lang, Bianca A.
AU - Li, Yuhui
AU - Oddis, Chester V.
AU - Olesinska, Marzena
AU - Reed, Ann M.
AU - Rutkowska-Sak, Lidia
AU - Sanner, Helga
AU - Selva-O'Callaghan, Albert
AU - Song, Yeong-Wook
AU - Vencovsky, Jiri
AU - Ytterberg, Steven R.
AU - Miller, Frederick W.
AU - Rider, Lisa G.
PY - 2017
Y1 - 2017
N2 - Objective To develop and validate new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIM) and their major subgroups. Methods Candidate variables were assembled from published criteria and expert opinion using consensus methodology. Data were collected from 47 rheumatology, dermatology, neurology and paediatric clinics worldwide. Several statistical methods were used to derive the classification criteria. Results Based on data from 976 IIM patients (74% adults; 26% children) and 624 non-IIM patients with mimicking conditions (82% adults; 18% children), new criteria were derived. Each item is assigned a weighted score. The total score corresponds to a probability of having IIM. Subclassification is performed using a classification tree. A probability cut-off of 55%, corresponding to a score of 5.5 (6.7 with muscle biopsy) 'probable IIM', had best sensitivity/specificity (87%/82% without biopsies, 93%/88% with biopsies) and is recommended as a minimum to classify a patient as having IIM. A probability of >= 90%, corresponding to a score of >= 7.5 (>= 8.7 with muscle biopsy), corresponds to 'definite IIM'. A probability of <50%, corresponding to a score of <5.3 ( <6.5 with muscle biopsy), rules out IIM, leaving a probability of >= 50 to <55% as 'possible IIM'. Conclusions The European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for IIM have been endorsed by international rheumatology, dermatology, neurology and paediatric groups. They employ easily accessible and operationally defined elements, and have been partially validated. They allow classification of 'definite', 'probable' and 'possible' IIM, in addition to the major subgroups of IIM, including juvenile IIM. They generally perform better than existing criteria
AB - Objective To develop and validate new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIM) and their major subgroups. Methods Candidate variables were assembled from published criteria and expert opinion using consensus methodology. Data were collected from 47 rheumatology, dermatology, neurology and paediatric clinics worldwide. Several statistical methods were used to derive the classification criteria. Results Based on data from 976 IIM patients (74% adults; 26% children) and 624 non-IIM patients with mimicking conditions (82% adults; 18% children), new criteria were derived. Each item is assigned a weighted score. The total score corresponds to a probability of having IIM. Subclassification is performed using a classification tree. A probability cut-off of 55%, corresponding to a score of 5.5 (6.7 with muscle biopsy) 'probable IIM', had best sensitivity/specificity (87%/82% without biopsies, 93%/88% with biopsies) and is recommended as a minimum to classify a patient as having IIM. A probability of >= 90%, corresponding to a score of >= 7.5 (>= 8.7 with muscle biopsy), corresponds to 'definite IIM'. A probability of <50%, corresponding to a score of <5.3 ( <6.5 with muscle biopsy), rules out IIM, leaving a probability of >= 50 to <55% as 'possible IIM'. Conclusions The European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for IIM have been endorsed by international rheumatology, dermatology, neurology and paediatric groups. They employ easily accessible and operationally defined elements, and have been partially validated. They allow classification of 'definite', 'probable' and 'possible' IIM, in addition to the major subgroups of IIM, including juvenile IIM. They generally perform better than existing criteria
U2 - https://doi.org/10.1136/annrheumdis-2017-211468
DO - https://doi.org/10.1136/annrheumdis-2017-211468
M3 - Article
C2 - 29079590
SN - 0003-4967
VL - 76
SP - 1955
EP - 1964
JO - Annals of the rheumatic diseases
JF - Annals of the rheumatic diseases
IS - 12
ER -