TY - JOUR
T1 - 2017 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups
AU - Lundberg, Ingrid E.
AU - Tjärnlund, Anna
AU - Bottai, Matteo
AU - Werth, Victoria P.
AU - Pilkington, Clarissa
AU - de Visser, Marianne
AU - Alfredsson, Lars
AU - Amato, Anthony A.
AU - Barohn, Richard J.
AU - Liang, Matthew H.
AU - Singh, Jasvinder A.
AU - Aggarwal, Rohit
AU - Arnardottir, Snjolaug
AU - Chinoy, Hector
AU - Cooper, Robert G.
AU - Dankó, Katalin
AU - Dimachkie, Mazen M.
AU - Feldman, Brian M.
AU - Garcia-de la Torre, Ignacio
AU - Gordon, Patrick
AU - Hayashi, Taichi
AU - Katz, James D.
AU - Kohsaka, Hitoshi
AU - Lachenbruch, Peter A.
AU - Lang, Bianca A.
AU - Li, Yuhui
AU - Oddis, Chester V.
AU - Olesinska, Marzena
AU - Reed, Ann M.
AU - Rutkowska-Sak, Lidia
AU - Sanner, Helga
AU - Selva-O'Callaghan, Albert
AU - Song, Yeong-Wook
AU - Vencovsky, Jiri
AU - Ytterberg, Steven R.
AU - Miller, Frederick W.
AU - Rider, Lisa G.
PY - 2017
Y1 - 2017
N2 - Objective. To develop and validate new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIM) and their major subgroups. Methods. Candidate variables were assembled from published criteria and expert opinion using consensus methodology. Data were collected from 47 rheumatology, dermatology, neurology, and pediatric clinics worldwide. Several statistical methods were utilized to derive the classification criteria. Results. Based on data from 976 IIM patients (74% adults; 26% children) and 624 non-IIM patients with mimicking conditions (82% adults; 18% children), new criteria were derived. Each item is assigned a weighted score. The total score corresponds to a probability of having IIM. Subclassification is performed using a classification tree. A probability cutoff of 55%, corresponding to a score of 5.5 (6.7 with muscle biopsy) "probable IIM," had best sensitivity/specificity (87%/82% without biopsies, 93%/88% with biopsies) and is recommended as a minimum to classify a patient as having IIM. A probability of >= 90%, corresponding to a score of >= 7.5 (>= 8.7 with muscle biopsy), corresponds to "definite IIM." A probability of <50%, corresponding to a score of <5.3 ( <6.5 with muscle biopsy), rules out IIM, leaving a probability of >= 50- <55% as "possible IIM." Conclusion. The European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for IIM have been endorsed by international rheumatology, dermatology, neurology, and pediatric groups. They employ easily accessible and operationally defined elements, and have been partially validated. They allow classification of "definite," "probable," and "possible" IIM, in addition to the major subgroups of IIM, including juvenile IIM. They generally perform better than existing criteria
AB - Objective. To develop and validate new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIM) and their major subgroups. Methods. Candidate variables were assembled from published criteria and expert opinion using consensus methodology. Data were collected from 47 rheumatology, dermatology, neurology, and pediatric clinics worldwide. Several statistical methods were utilized to derive the classification criteria. Results. Based on data from 976 IIM patients (74% adults; 26% children) and 624 non-IIM patients with mimicking conditions (82% adults; 18% children), new criteria were derived. Each item is assigned a weighted score. The total score corresponds to a probability of having IIM. Subclassification is performed using a classification tree. A probability cutoff of 55%, corresponding to a score of 5.5 (6.7 with muscle biopsy) "probable IIM," had best sensitivity/specificity (87%/82% without biopsies, 93%/88% with biopsies) and is recommended as a minimum to classify a patient as having IIM. A probability of >= 90%, corresponding to a score of >= 7.5 (>= 8.7 with muscle biopsy), corresponds to "definite IIM." A probability of <50%, corresponding to a score of <5.3 ( <6.5 with muscle biopsy), rules out IIM, leaving a probability of >= 50- <55% as "possible IIM." Conclusion. The European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for IIM have been endorsed by international rheumatology, dermatology, neurology, and pediatric groups. They employ easily accessible and operationally defined elements, and have been partially validated. They allow classification of "definite," "probable," and "possible" IIM, in addition to the major subgroups of IIM, including juvenile IIM. They generally perform better than existing criteria
U2 - https://doi.org/10.1002/art.40320
DO - https://doi.org/10.1002/art.40320
M3 - Article
C2 - 29106061
SN - 2326-5191
VL - 69
SP - 2271
EP - 2282
JO - Arthritis & rheumatology (Hoboken, N.J.)
JF - Arthritis & rheumatology (Hoboken, N.J.)
IS - 12
ER -