TY - JOUR
T1 - 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy
AU - Towbin, Jeffrey A.
AU - McKenna, William J.
AU - Abrams, Dominic J.
AU - Ackerman, Michael J.
AU - Calkins, Hugh
AU - Darrieux, Francisco C. C.
AU - Daubert, James P.
AU - de Chillou, Christian
AU - DePasquale, Eugene C.
AU - Desai, Milind Y.
AU - Estes, N. A. Mark
AU - Hua, Wei
AU - Indik, Julia H.
AU - Ingles, Jodie
AU - James, Cynthia A.
AU - John, Roy M.
AU - Judge, Daniel P.
AU - Keegan, Roberto
AU - Krahn, Andrew D.
AU - Link, Mark S.
AU - Marcus, Frank I.
AU - McLeod, Christopher J.
AU - Mestroni, Luisa
AU - Priori, Silvia G.
AU - Saffitz, Jeffrey E.
AU - Sanatani, Shubhayan
AU - Shimizu, Wataru
AU - van Tintelen, J. Peter
AU - Wilde, Arthur A. M.
AU - Zareba, Wojciech
PY - 2019
Y1 - 2019
N2 - Arrhythmogenic cardiomyopathy (ACM) is an arrhythmogenic disorder of the myocardium not secondary to ischemic, hypertensive, or valvular heart disease. ACM incorporates a broad spectrum of genetic, systemic, infectious, and inflammatory disorders. This designation includes, but is not limited to, arrhythmogenic right/left ventricular cardiomyopathy, cardiac amyloidosis, sarcoidosis, Chagas disease, and left ventricular noncompaction. The ACM phenotype overlaps with other cardiomyopathies, particularly dilated cardiomyopathy with arrhythmia presentation that may be associated with ventricular dilatation and/or impaired systolic function. This expert consensus statement provides the clinician with guidance on evaluation and management of ACM and includes clinically relevant information on genetics and disease mechanisms. PICO questions were utilized to evaluate contemporary evidence and provide clinical guidance related to exercise in arrhythmogenic right ventricular cardiomyopathy. Recommendations were developed and approved by an expert writing group, after a systematic literature search with evidence tables, and discussion of their own clinical experience, to present the current knowledge in the field. Each recommendation is presented using the Class of Recommendation and Level of Evidence system formulated by the American College of Cardiology and the American Heart Association and is accompanied by references and explanatory text to provide essential context. The ongoing recognition of the genetic basis of ACM provides the opportunity to examine the diverse triggers and potential common pathway for the development of disease and arrhythmia.
AB - Arrhythmogenic cardiomyopathy (ACM) is an arrhythmogenic disorder of the myocardium not secondary to ischemic, hypertensive, or valvular heart disease. ACM incorporates a broad spectrum of genetic, systemic, infectious, and inflammatory disorders. This designation includes, but is not limited to, arrhythmogenic right/left ventricular cardiomyopathy, cardiac amyloidosis, sarcoidosis, Chagas disease, and left ventricular noncompaction. The ACM phenotype overlaps with other cardiomyopathies, particularly dilated cardiomyopathy with arrhythmia presentation that may be associated with ventricular dilatation and/or impaired systolic function. This expert consensus statement provides the clinician with guidance on evaluation and management of ACM and includes clinically relevant information on genetics and disease mechanisms. PICO questions were utilized to evaluate contemporary evidence and provide clinical guidance related to exercise in arrhythmogenic right ventricular cardiomyopathy. Recommendations were developed and approved by an expert writing group, after a systematic literature search with evidence tables, and discussion of their own clinical experience, to present the current knowledge in the field. Each recommendation is presented using the Class of Recommendation and Level of Evidence system formulated by the American College of Cardiology and the American Heart Association and is accompanied by references and explanatory text to provide essential context. The ongoing recognition of the genetic basis of ACM provides the opportunity to examine the diverse triggers and potential common pathway for the development of disease and arrhythmia.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85068265159&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31078652
U2 - https://doi.org/10.1016/j.hrthm.2019.05.007
DO - https://doi.org/10.1016/j.hrthm.2019.05.007
M3 - Article
C2 - 31078652
SN - 1547-5271
VL - 16
SP - e301-e372
JO - Heart Rhythm
JF - Heart Rhythm
IS - 11
ER -