2019 update of the European AIDS Clinical Society Guidelines for treatment of people living with HIV version 10.0

L. Ryom; A. Cotter; R. de Miguel; C. Béguelin; D. Podlekareva; J. R. Arribas; C. Marzolini; P. G. M. Mallon; A. Rauch; O. Kirk; J. M. Molina; G. Guaraldi; A. Winston; S. Bhagani; P. Cinque; J. D. Kowalska; S. Collins; M. Battegay; Rosa de Miguel Buckley; Antonella d'Arminio Monforte; Margherita Bracchi; Nikos Dedes; Andrzej Horban; Christine Katlama; Inga Latysheva; Jens D. Lundgren; Sheena McCormack; Cristina Mussini; Anton Pozniak; Federico Pulido; François Raffi; Peter Reiss; Hans-J. rgen Stellbrink; Marta Vasylyev; Sara Gibbons; Françoise Livio; Georg Behrens; Mark Bower; Juliet Compston; Stéphane de Wit; Leonardo M. Fabbri; Christoph A. Fux; Magnus Gisslen; Jens D. Lundgren; Esteban Martínez; José M. Miro; Eugenia Negredo; Neil Poulter; Peter Reiss; Giada Sebastiani; Juan Berenguer; Christoph Boesecke; Raffaele Bruno; Svilen Konov; Karine Lacombe; Stefan Mauss; Luís Mendão; Lars Peters; Massimo Puoti; J. rgen K. Rockstroh; Juan Ambrosioni; Nathalie de Castro; Gerd Fätkenheuer; Hansjakob Furrer; José M. Miro; Cristiana Oprea; Anton Pozniak; Alain Volny-Anne; J. rgen K. Rockstroh; Ann Sullivan; Esteban Martínez; Fiona Mulcahy; Antonella d'Arminio Monforte; Georg Behrens; Christine Katlama; Jens D. Lundgren; Cristina Mussini; Cristiana Oprea; Anton Pozniak; Peter Reiss; Annemarie Wensing

doi:https://doi.org/10.1111/hiv.12878

2019 update of the European AIDS Clinical Society Guidelines for treatment of people living with HIV version 10.0

L. Ryom, A. Cotter, R. de Miguel, C. Béguelin, D. Podlekareva, J. R. Arribas, C. Marzolini, P. G. M. Mallon, A. Rauch, O. Kirk, J. M. Molina, G. Guaraldi, A. Winston, S. Bhagani, P. Cinque, J. D. Kowalska, S. Collins, M. Battegay, Rosa de Miguel Buckley, Antonella d'Arminio MonforteMargherita Bracchi, Nikos Dedes, Andrzej Horban, Christine Katlama, Inga Latysheva, Jens D. Lundgren, Sheena McCormack, Cristina Mussini, Anton Pozniak, Federico Pulido, François Raffi, Peter Reiss, Hans-J. rgen Stellbrink, Marta Vasylyev, Sara Gibbons, Françoise Livio, Georg Behrens, Mark Bower, Juliet Compston, Stéphane de Wit, Leonardo M. Fabbri, Christoph A. Fux, Magnus Gisslen, Jens D. Lundgren, Esteban Martínez, José M. Miro, Eugenia Negredo, Neil Poulter, Peter Reiss, Giada Sebastiani, Juan Berenguer, Christoph Boesecke, Raffaele Bruno, Svilen Konov, Karine Lacombe, Stefan Mauss, Luís Mendão, Lars Peters, Massimo Puoti, J. rgen K. Rockstroh, Juan Ambrosioni, Nathalie de Castro, Gerd Fätkenheuer, Hansjakob Furrer, José M. Miro, Cristiana Oprea, Anton Pozniak, Alain Volny-Anne, J. rgen K. Rockstroh, Ann Sullivan, Esteban Martínez, Fiona Mulcahy, Antonella d'Arminio Monforte, Georg Behrens, Christine Katlama, Jens D. Lundgren, Cristina Mussini, Cristiana Oprea, Anton Pozniak, Peter Reiss, Annemarie Wensing

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Abstract

Background: The European AIDS Clinical Society (EACS) Guidelines cover key aspects of HIV management with major updates every two years. Guideline highlights: The 2019 Guidelines were extended with a new section focusing on drug–drug interactions and other prescribing issues in people living with HIV (PLWH). The recommendations for treatment-naïve PLWH were updated with four preferred regimens favouring unboosted integrase inhibitors. A two-drug regimen with dolutegravir and lamivudine, and a three-drug regimen including doravirine were also added to the recommended initial regimens. Lower thresholds for hypertension were expanded to all PLWH and for cardiovascular disease prevention, the 10-year predicted risk threshold for consideration of antiretroviral therapy (ART) modification was lowered from 20% to 10%. Frailty and obesity were added as new topics. It was specified to use urine albumin to creatinine ratio to screen for glomerular disease and urine protein to creatinine ratio for tubular diseases, and thresholds were streamlined with the Kidney Disease: Improving Global Outcomes (KDIGO) recommendations. Hepatitis C virus (HCV) treatment recommendations were split into preferred and alternative treatment options. The algorithm for management of recently acquired HCV infection was updated and includes recommendations for early chronic infection management. Treatment of resistant tuberculosis (TB) was streamlined with the World Health Organization (WHO) recommendations, and new tables on immune reconstitution inflammatory syndrome, on when to start ART in the presence of opportunistic infections and on TB drug dosing were included. Conclusions: The EACS Guidelines underwent major revisions of all sections in 2019. They are available in four different formats including a new interactive web-based version and are translated into Chinese, French, German, Japanese, Portuguese, Russian and Spanish.

Original language	English
Pages (from-to)	617-624
Number of pages	8
Journal	HIV medicine
Volume	21
Issue number	10
Early online date	2020
DOIs	https://doi.org/10.1111/hiv.12878
Publication status	Published - 1 Nov 2020

Keywords

European AIDS Clinical Society (EACS) Guidelines
HIV
antiretroviral treatment
comorbidities
drug–drug interactions
hepatitis B virus
hepatitis C virus
opportunistic infections
prescribing in elderly patients

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Ryom, L., Cotter, A., de Miguel, R., Béguelin, C., Podlekareva, D., Arribas, J. R., Marzolini, C., Mallon, P. G. M., Rauch, A., Kirk, O., Molina, J. M., Guaraldi, G., Winston, A., Bhagani, S., Cinque, P., Kowalska, J. D., Collins, S., Battegay, M., de Miguel Buckley, R., ... Wensing, A. (2020). 2019 update of the European AIDS Clinical Society Guidelines for treatment of people living with HIV version 10.0. HIV medicine, 21(10), 617-624. https://doi.org/10.1111/hiv.12878

@article{a4fae3ac1c0444bfbd71272ba56cae8b,

title = "2019 update of the European AIDS Clinical Society Guidelines for treatment of people living with HIV version 10.0",

abstract = "Background: The European AIDS Clinical Society (EACS) Guidelines cover key aspects of HIV management with major updates every two years. Guideline highlights: The 2019 Guidelines were extended with a new section focusing on drug–drug interactions and other prescribing issues in people living with HIV (PLWH). The recommendations for treatment-na{\"i}ve PLWH were updated with four preferred regimens favouring unboosted integrase inhibitors. A two-drug regimen with dolutegravir and lamivudine, and a three-drug regimen including doravirine were also added to the recommended initial regimens. Lower thresholds for hypertension were expanded to all PLWH and for cardiovascular disease prevention, the 10-year predicted risk threshold for consideration of antiretroviral therapy (ART) modification was lowered from 20% to 10%. Frailty and obesity were added as new topics. It was specified to use urine albumin to creatinine ratio to screen for glomerular disease and urine protein to creatinine ratio for tubular diseases, and thresholds were streamlined with the Kidney Disease: Improving Global Outcomes (KDIGO) recommendations. Hepatitis C virus (HCV) treatment recommendations were split into preferred and alternative treatment options. The algorithm for management of recently acquired HCV infection was updated and includes recommendations for early chronic infection management. Treatment of resistant tuberculosis (TB) was streamlined with the World Health Organization (WHO) recommendations, and new tables on immune reconstitution inflammatory syndrome, on when to start ART in the presence of opportunistic infections and on TB drug dosing were included. Conclusions: The EACS Guidelines underwent major revisions of all sections in 2019. They are available in four different formats including a new interactive web-based version and are translated into Chinese, French, German, Japanese, Portuguese, Russian and Spanish.",

keywords = "European AIDS Clinical Society (EACS) Guidelines, HIV, antiretroviral treatment, comorbidities, drug–drug interactions, hepatitis B virus, hepatitis C virus, opportunistic infections, prescribing in elderly patients",

author = "L. Ryom and A. Cotter and {de Miguel}, R. and C. B{\'e}guelin and D. Podlekareva and Arribas, {J. R.} and C. Marzolini and Mallon, {P. G. M.} and A. Rauch and O. Kirk and Molina, {J. M.} and G. Guaraldi and A. Winston and S. Bhagani and P. Cinque and Kowalska, {J. D.} and S. Collins and M. Battegay and {de Miguel Buckley}, Rosa and {d'Arminio Monforte}, Antonella and Margherita Bracchi and Nikos Dedes and Andrzej Horban and Christine Katlama and Inga Latysheva and Lundgren, {Jens D.} and Sheena McCormack and Cristina Mussini and Anton Pozniak and Federico Pulido and Fran{\c c}ois Raffi and Peter Reiss and Stellbrink, {Hans-J. rgen} and Marta Vasylyev and Sara Gibbons and Fran{\c c}oise Livio and Georg Behrens and Mark Bower and Juliet Compston and {de Wit}, St{\'e}phane and Fabbri, {Leonardo M.} and Fux, {Christoph A.} and Magnus Gisslen and Lundgren, {Jens D.} and Esteban Mart{\'i}nez and Miro, {Jos{\'e} M.} and Eugenia Negredo and Neil Poulter and Peter Reiss and Giada Sebastiani and Juan Berenguer and Christoph Boesecke and Raffaele Bruno and Svilen Konov and Karine Lacombe and Stefan Mauss and Lu{\'i}s Mend{\~a}o and Lars Peters and Massimo Puoti and Rockstroh, {J. rgen K.} and Juan Ambrosioni and {de Castro}, Nathalie and Gerd F{\"a}tkenheuer and Hansjakob Furrer and Miro, {Jos{\'e} M.} and Cristiana Oprea and Anton Pozniak and Alain Volny-Anne and Rockstroh, {J. rgen K.} and Ann Sullivan and Esteban Mart{\'i}nez and Fiona Mulcahy and {d'Arminio Monforte}, Antonella and Georg Behrens and Christine Katlama and Lundgren, {Jens D.} and Cristina Mussini and Cristiana Oprea and Anton Pozniak and Peter Reiss and Annemarie Wensing",

year = "2020",

month = nov,

day = "1",

doi = "https://doi.org/10.1111/hiv.12878",

language = "English",

volume = "21",

pages = "617--624",

journal = "HIV medicine",

issn = "1464-2662",

publisher = "BioMed Central",

number = "10",

}

Ryom, L, Cotter, A, de Miguel, R, Béguelin, C, Podlekareva, D, Arribas, JR, Marzolini, C, Mallon, PGM, Rauch, A, Kirk, O, Molina, JM, Guaraldi, G, Winston, A, Bhagani, S, Cinque, P, Kowalska, JD, Collins, S, Battegay, M, de Miguel Buckley, R, d'Arminio Monforte, A, Bracchi, M, Dedes, N, Horban, A, Katlama, C, Latysheva, I, Lundgren, JD, McCormack, S, Mussini, C, Pozniak, A, Pulido, F, Raffi, F, Reiss, P, Stellbrink, H-JR, Vasylyev, M, Gibbons, S, Livio, F, Behrens, G, Bower, M, Compston, J, de Wit, S, Fabbri, LM, Fux, CA, Gisslen, M, Lundgren, JD, Martínez, E, Miro, JM, Negredo, E, Poulter, N, Reiss, P, Sebastiani, G, Berenguer, J, Boesecke, C, Bruno, R, Konov, S, Lacombe, K, Mauss, S, Mendão, L, Peters, L, Puoti, M, Rockstroh, JRK, Ambrosioni, J, de Castro, N, Fätkenheuer, G, Furrer, H, Miro, JM, Oprea, C, Pozniak, A, Volny-Anne, A, Rockstroh, JRK, Sullivan, A, Martínez, E, Mulcahy, F, d'Arminio Monforte, A, Behrens, G, Katlama, C, Lundgren, JD, Mussini, C, Oprea, C, Pozniak, A, Reiss, P & Wensing, A 2020, '2019 update of the European AIDS Clinical Society Guidelines for treatment of people living with HIV version 10.0', HIV medicine, vol. 21, no. 10, pp. 617-624. https://doi.org/10.1111/hiv.12878

TY - JOUR

T1 - 2019 update of the European AIDS Clinical Society Guidelines for treatment of people living with HIV version 10.0

AU - Ryom, L.

AU - Cotter, A.

AU - de Miguel, R.

AU - Béguelin, C.

AU - Podlekareva, D.

AU - Arribas, J. R.

AU - Marzolini, C.

AU - Mallon, P. G. M.

AU - Rauch, A.

AU - Kirk, O.

AU - Molina, J. M.

AU - Guaraldi, G.

AU - Winston, A.

AU - Bhagani, S.

AU - Cinque, P.

AU - Kowalska, J. D.

AU - Collins, S.

AU - Battegay, M.

AU - de Miguel Buckley, Rosa

AU - d'Arminio Monforte, Antonella

AU - Bracchi, Margherita

AU - Dedes, Nikos

AU - Horban, Andrzej

AU - Katlama, Christine

AU - Latysheva, Inga

AU - Lundgren, Jens D.

AU - McCormack, Sheena

AU - Mussini, Cristina

AU - Pozniak, Anton

AU - Pulido, Federico

AU - Raffi, François

AU - Reiss, Peter

AU - Stellbrink, Hans-J. rgen

AU - Vasylyev, Marta

AU - Gibbons, Sara

AU - Livio, Françoise

AU - Behrens, Georg

AU - Bower, Mark

AU - Compston, Juliet

AU - de Wit, Stéphane

AU - Fabbri, Leonardo M.

AU - Fux, Christoph A.

AU - Gisslen, Magnus

AU - Lundgren, Jens D.

AU - Martínez, Esteban

AU - Miro, José M.

AU - Negredo, Eugenia

AU - Poulter, Neil

AU - Reiss, Peter

AU - Sebastiani, Giada

AU - Berenguer, Juan

AU - Boesecke, Christoph

AU - Bruno, Raffaele

AU - Konov, Svilen

AU - Lacombe, Karine

AU - Mauss, Stefan

AU - Mendão, Luís

AU - Peters, Lars

AU - Puoti, Massimo

AU - Rockstroh, J. rgen K.

AU - Ambrosioni, Juan

AU - de Castro, Nathalie

AU - Fätkenheuer, Gerd

AU - Furrer, Hansjakob

AU - Miro, José M.

AU - Oprea, Cristiana

AU - Pozniak, Anton

AU - Volny-Anne, Alain

AU - Rockstroh, J. rgen K.

AU - Sullivan, Ann

AU - Martínez, Esteban

AU - Mulcahy, Fiona

AU - d'Arminio Monforte, Antonella

AU - Behrens, Georg

AU - Katlama, Christine

AU - Lundgren, Jens D.

AU - Mussini, Cristina

AU - Oprea, Cristiana

AU - Pozniak, Anton

AU - Reiss, Peter

AU - Wensing, Annemarie

PY - 2020/11/1

Y1 - 2020/11/1

N2 - Background: The European AIDS Clinical Society (EACS) Guidelines cover key aspects of HIV management with major updates every two years. Guideline highlights: The 2019 Guidelines were extended with a new section focusing on drug–drug interactions and other prescribing issues in people living with HIV (PLWH). The recommendations for treatment-naïve PLWH were updated with four preferred regimens favouring unboosted integrase inhibitors. A two-drug regimen with dolutegravir and lamivudine, and a three-drug regimen including doravirine were also added to the recommended initial regimens. Lower thresholds for hypertension were expanded to all PLWH and for cardiovascular disease prevention, the 10-year predicted risk threshold for consideration of antiretroviral therapy (ART) modification was lowered from 20% to 10%. Frailty and obesity were added as new topics. It was specified to use urine albumin to creatinine ratio to screen for glomerular disease and urine protein to creatinine ratio for tubular diseases, and thresholds were streamlined with the Kidney Disease: Improving Global Outcomes (KDIGO) recommendations. Hepatitis C virus (HCV) treatment recommendations were split into preferred and alternative treatment options. The algorithm for management of recently acquired HCV infection was updated and includes recommendations for early chronic infection management. Treatment of resistant tuberculosis (TB) was streamlined with the World Health Organization (WHO) recommendations, and new tables on immune reconstitution inflammatory syndrome, on when to start ART in the presence of opportunistic infections and on TB drug dosing were included. Conclusions: The EACS Guidelines underwent major revisions of all sections in 2019. They are available in four different formats including a new interactive web-based version and are translated into Chinese, French, German, Japanese, Portuguese, Russian and Spanish.

AB - Background: The European AIDS Clinical Society (EACS) Guidelines cover key aspects of HIV management with major updates every two years. Guideline highlights: The 2019 Guidelines were extended with a new section focusing on drug–drug interactions and other prescribing issues in people living with HIV (PLWH). The recommendations for treatment-naïve PLWH were updated with four preferred regimens favouring unboosted integrase inhibitors. A two-drug regimen with dolutegravir and lamivudine, and a three-drug regimen including doravirine were also added to the recommended initial regimens. Lower thresholds for hypertension were expanded to all PLWH and for cardiovascular disease prevention, the 10-year predicted risk threshold for consideration of antiretroviral therapy (ART) modification was lowered from 20% to 10%. Frailty and obesity were added as new topics. It was specified to use urine albumin to creatinine ratio to screen for glomerular disease and urine protein to creatinine ratio for tubular diseases, and thresholds were streamlined with the Kidney Disease: Improving Global Outcomes (KDIGO) recommendations. Hepatitis C virus (HCV) treatment recommendations were split into preferred and alternative treatment options. The algorithm for management of recently acquired HCV infection was updated and includes recommendations for early chronic infection management. Treatment of resistant tuberculosis (TB) was streamlined with the World Health Organization (WHO) recommendations, and new tables on immune reconstitution inflammatory syndrome, on when to start ART in the presence of opportunistic infections and on TB drug dosing were included. Conclusions: The EACS Guidelines underwent major revisions of all sections in 2019. They are available in four different formats including a new interactive web-based version and are translated into Chinese, French, German, Japanese, Portuguese, Russian and Spanish.

KW - European AIDS Clinical Society (EACS) Guidelines

KW - HIV

KW - antiretroviral treatment

KW - comorbidities

KW - drug–drug interactions

KW - hepatitis B virus

KW - hepatitis C virus

KW - opportunistic infections

KW - prescribing in elderly patients

UR - http://www.scopus.com/inward/record.url?scp=85092011161&partnerID=8YFLogxK

U2 - https://doi.org/10.1111/hiv.12878

DO - https://doi.org/10.1111/hiv.12878

M3 - Article

C2 - 32885559

SN - 1464-2662

VL - 21

SP - 617

EP - 624

JO - HIV medicine

JF - HIV medicine

IS - 10

ER -

2019 update of the European AIDS Clinical Society Guidelines for treatment of people living with HIV version 10.0

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Keywords

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