TY - JOUR
T1 - Shaping the risk for late-life neurodegenerative disease
T2 - A systematic review on prenatal risk factors for Alzheimer's disease-related volumetric brain biomarkers
AU - Boots, A.
AU - Wiegersma, A. M.
AU - Vali, Y.
AU - van den Hof, M.
AU - Langendam, M. W.
AU - Limpens, J.
AU - Backhouse, E. V.
AU - Shenkin, S. D.
AU - Wardlaw, J. M.
AU - Roseboom, T. J.
AU - de Rooij, S. R.
N1 - Funding Information: This work was supported by a Dutch Research Council (NWO) Aspasia grant awarded to S.R. de Rooij and by the European Commission Horizon 2020 , project LongITools [grant numbers 015014039, 874739 ]. The funding organizations had no role in the design and preparation of this review. Publisher Copyright: © 2023 The Authors
PY - 2023/3/1
Y1 - 2023/3/1
N2 - Environmental exposures including toxins and nutrition may hamper the developing brain in utero, limiting the brain's reserve capacity and increasing the risk for Alzheimer's disease (AD). The purpose of this systematic review is to summarize all currently available evidence for the association between prenatal exposures and AD-related volumetric brain biomarkers. We systematically searched MEDLINE and Embase for studies in humans reporting on associations between prenatal exposure(s) and AD-related volumetric brain biomarkers, including whole brain volume (WBV), hippocampal volume (HV) and/or temporal lobe volume (TLV) measured with structural magnetic resonance imaging (PROSPERO; CRD42020169317). Risk of bias was assessed using the Newcastle Ottawa Scale. We identified 79 eligible studies (search date: August 30th, 2020; Ntotal=24,784; median age 10.7 years) reporting on WBV (N = 38), HV (N = 63) and/or TLV (N = 5) in exposure categories alcohol (N = 30), smoking (N = 7), illicit drugs (N = 14), mental health problems (N = 7), diet (N = 8), disease, treatment and physiology (N = 10), infections (N = 6) and environmental exposures (N = 3). Overall risk of bias was low. Prenatal exposure to alcohol, opioids, cocaine, nutrient shortage, placental dysfunction and maternal anemia was associated with smaller brain volumes. We conclude that the prenatal environment is important in shaping the risk for late-life neurodegenerative disease.
AB - Environmental exposures including toxins and nutrition may hamper the developing brain in utero, limiting the brain's reserve capacity and increasing the risk for Alzheimer's disease (AD). The purpose of this systematic review is to summarize all currently available evidence for the association between prenatal exposures and AD-related volumetric brain biomarkers. We systematically searched MEDLINE and Embase for studies in humans reporting on associations between prenatal exposure(s) and AD-related volumetric brain biomarkers, including whole brain volume (WBV), hippocampal volume (HV) and/or temporal lobe volume (TLV) measured with structural magnetic resonance imaging (PROSPERO; CRD42020169317). Risk of bias was assessed using the Newcastle Ottawa Scale. We identified 79 eligible studies (search date: August 30th, 2020; Ntotal=24,784; median age 10.7 years) reporting on WBV (N = 38), HV (N = 63) and/or TLV (N = 5) in exposure categories alcohol (N = 30), smoking (N = 7), illicit drugs (N = 14), mental health problems (N = 7), diet (N = 8), disease, treatment and physiology (N = 10), infections (N = 6) and environmental exposures (N = 3). Overall risk of bias was low. Prenatal exposure to alcohol, opioids, cocaine, nutrient shortage, placental dysfunction and maternal anemia was associated with smaller brain volumes. We conclude that the prenatal environment is important in shaping the risk for late-life neurodegenerative disease.
KW - Alzheimer's disease
KW - Brain reserve
KW - Developmental programming
KW - MRI
KW - Systematic review
UR - http://www.scopus.com/inward/record.url?scp=85147102912&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.neubiorev.2022.105019
DO - https://doi.org/10.1016/j.neubiorev.2022.105019
M3 - Review article
C2 - 36608918
SN - 0149-7634
VL - 146
SP - 105019
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
M1 - 105019
ER -