BRAFV600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis

Aldo A. Acosta-Medina; Paul G. Kemps; Timo C. E. Zondag; Jithma P. Abeykoon; Jelske Forma-Borst; Eline C. Steenwijk; Elizabeth A. M. Feijen; Jop C. Teepen; N. Nora Bennani; Susan M. Schram; Mithun V. Shah; Caroline Davidge-Pitts; Matthew J. Koster; Jay H. Ryu; Robert Vassallo; W. Oliver Tobin; Jason R. Young; Surendra Dasari; Karen Rech; Aishwarya Ravindran; Arjen H. G. Cleven; Robert M. Verdijk; Carel J. M. van Noesel; Brian V. Balgobind; Gerrit Joan Bouma; Peerooz Saeed; Jos A. M. Bramer; Ruben A. L. de Groen; Joost S. P. Vermaat; Michiel A. J. van de Sande; Egbert F. Smit; Anton W. Langerak; Tom van Wezel; Sanne H. Tonino; Cor van den Bos; Jan A. M. van Laar; Ronald S. Go; Gaurav Goyal; Astrid G. S. van Halteren

doi:https://doi.org/10.1182/blood.2023021212

BRAFV600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis

Aldo A. Acosta-Medina, Paul G. Kemps, Timo C. E. Zondag, Jithma P. Abeykoon, Jelske Forma-Borst, Eline C. Steenwijk, Elizabeth A. M. Feijen, Jop C. Teepen, N. Nora Bennani, Susan M. Schram, Mithun V. Shah, Caroline Davidge-Pitts, Matthew J. Koster, Jay H. Ryu, Robert Vassallo, W. Oliver Tobin, Jason R. Young, Surendra Dasari, Karen Rech, Aishwarya RavindranArjen H. G. Cleven, Robert M. Verdijk, Carel J. M. van Noesel, Brian V. Balgobind, Gerrit Joan Bouma, Peerooz Saeed, Jos A. M. Bramer, Ruben A. L. de Groen, Joost S. P. Vermaat, Michiel A. J. van de Sande, Egbert F. Smit, Anton W. Langerak, Tom van Wezel, Sanne H. Tonino, Cor van den Bos, Jan A. M. van Laar, Ronald S. Go, Gaurav Goyal, Astrid G. S. van Halteren

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

Abstract

In this retrospective study, BRAF mutation status did not correlate with disease extent or (event-free) survival in 156 adults with Langerhans cell histiocytosis. BRAFV600E was associated with an increased incidence of second malignancies, often comprising hematological cancers, which may be clonally related.

Original language	English
Pages (from-to)	1570-1575
Number of pages	6
Journal	Blood
Volume	142
Issue number	18
Early online date	2023
DOIs	https://doi.org/10.1182/blood.2023021212
Publication status	Published - 2 Nov 2023

Access to Document

https://doi.org/10.1182/blood.2023021212

Cite this

Acosta-Medina, A. A., Kemps, P. G., Zondag, T. C. E., Abeykoon, J. P., Forma-Borst, J., Steenwijk, E. C., Feijen, E. A. M., Teepen, J. C., Bennani, N. N., Schram, S. M., Shah, M. V., Davidge-Pitts, C., Koster, M. J., Ryu, J. H., Vassallo, R., Tobin, W. O., Young, J. R., Dasari, S., Rech, K., ... van Halteren, A. G. S. (2023). BRAFV600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis. Blood, 142(18), 1570-1575. https://doi.org/10.1182/blood.2023021212

@article{242734730e7042218c4af01081fcc33c,

title = "BRAFV600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis",

abstract = "In this retrospective study, BRAF mutation status did not correlate with disease extent or (event-free) survival in 156 adults with Langerhans cell histiocytosis. BRAFV600E was associated with an increased incidence of second malignancies, often comprising hematological cancers, which may be clonally related.",

author = "Acosta-Medina, {Aldo A.} and Kemps, {Paul G.} and Zondag, {Timo C. E.} and Abeykoon, {Jithma P.} and Jelske Forma-Borst and Steenwijk, {Eline C.} and Feijen, {Elizabeth A. M.} and Teepen, {Jop C.} and Bennani, {N. Nora} and Schram, {Susan M.} and Shah, {Mithun V.} and Caroline Davidge-Pitts and Koster, {Matthew J.} and Ryu, {Jay H.} and Robert Vassallo and Tobin, {W. Oliver} and Young, {Jason R.} and Surendra Dasari and Karen Rech and Aishwarya Ravindran and Cleven, {Arjen H. G.} and Verdijk, {Robert M.} and {van Noesel}, {Carel J. M.} and Balgobind, {Brian V.} and Bouma, {Gerrit Joan} and Peerooz Saeed and Bramer, {Jos A. M.} and {de Groen}, {Ruben A. L.} and Vermaat, {Joost S. P.} and {van de Sande}, {Michiel A. J.} and Smit, {Egbert F.} and Langerak, {Anton W.} and {van Wezel}, Tom and Tonino, {Sanne H.} and {van den Bos}, Cor and {van Laar}, {Jan A. M.} and Go, {Ronald S.} and Gaurav Goyal and {van Halteren}, {Astrid G. S.}",

note = "Funding Information: The authors thank the molecular diagnostics staff of the Department of Pathology of Leiden University Medical Center, as well as Michelle van der Klift, Fleur de Groot, Patty Jansen, and Karoly Szuhai for their help with genetic analyses. Sofie Breuking is acknowledged for prior work on the systematic review. The authors also thank Wichor Bramer from the Erasmus MC Medical Library for developing and updating the search strategies for the systematic review. Figure 1G-H was made with BioRender.com software. This study was supported by grants from Stichting 1000 Kaarsjes voor Juultje to A.G.S.v.H. the University of Iowa/Mayo Clinic Lymphoma SPORE P50 CA97274 to G.G. and J.P.A. and the Walter B. Frommeyer, Jr, Fellowship Award in Investigative Medicine, University of Alabama at Birmingham, to G.G. P.G.K. received an MD/PhD grant from Leiden University Medical Center. Contribution: C.v.d.B. J.A.M.v.L. R.S.G. G.G. and A.G.S.v.H. conceived the study; A.A.A.-M. P.G.K. T.C.E.Z. and J.P.A. collected clinical data; P.G.K. J.F.-B. E.C.S. S.D. R.A.L.d.G. A.W.L. T.v.W. and A.G.S.v.H. performed additional molecular genetic analyses outside routine diagnostics; P.G.K. analyzed the combined clinicogenomic data set and drafted the (supplemental) figures and tables; T.C.E.Z. performed the systematic review and meta-analysis, with P.G.K. as second assessor; E.A.M.F. supervised the systematic review and statistical analyses; J.C.T. helped with calculating standardized incidence ratios for second cancers; A.A.A.-M. P.G.K. T.C.E.Z. R.S.G. G.G. and A.G.S.v.H. drafted the manuscript; A.A.A.-M. J.P.A. N.N.B. S.M.S. M.V.S. C.D.-P. M.J.K. J.H.R. R.V. W.O.T. J.R.Y. K.R. A.R. A.H.G.C. R.M.V. C.J.M.v.N. B.V.B. G.J.B. P.S. J.A.M.B. J.S.P.V. M.A.J.v.d.S. E.F.S. S.H.T. C.v.d.B. J.A.M.v.L. R.S.G. and G.G. were involved in clinical care for included patients; and all authors critically reviewed and approved the manuscript. Funding Information: This study was supported by grants from Stichting 1000 Kaarsjes voor Juultje to A.G.S.v.H., the University of Iowa / Mayo Clinic Lymphoma SPORE P50 CA97274 to G.G. and J.P.A., and the Walter B. Frommeyer, Jr, Fellowship Award in Investigative Medicine, University of Alabama at Birmingham , to G.G. P.G.K. received an MD/PhD grant from Leiden University Medical Center . Publisher Copyright: {\textcopyright} 2023 The American Society of Hematology",

year = "2023",

month = nov,

day = "2",

doi = "https://doi.org/10.1182/blood.2023021212",

language = "English",

volume = "142",

pages = "1570--1575",

journal = "Blood",

issn = "0006-4971",

publisher = "American Society of Hematology",

number = "18",

}

Acosta-Medina, AA, Kemps, PG, Zondag, TCE, Abeykoon, JP, Forma-Borst, J, Steenwijk, EC, Feijen, EAM, Teepen, JC, Bennani, NN, Schram, SM, Shah, MV, Davidge-Pitts, C, Koster, MJ, Ryu, JH, Vassallo, R, Tobin, WO, Young, JR, Dasari, S, Rech, K, Ravindran, A, Cleven, AHG, Verdijk, RM, van Noesel, CJM , Balgobind, BV , Bouma, GJ , Saeed, P , Bramer, JAM, de Groen, RAL, Vermaat, JSP, van de Sande, MAJ, Smit, EF, Langerak, AW, van Wezel, T, Tonino, SH , van den Bos, C, van Laar, JAM, Go, RS, Goyal, G & van Halteren, AGS 2023, 'BRAFV600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis', Blood, vol. 142, no. 18, pp. 1570-1575. https://doi.org/10.1182/blood.2023021212

TY - JOUR

T1 - BRAFV600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis

AU - Acosta-Medina, Aldo A.

AU - Kemps, Paul G.

AU - Zondag, Timo C. E.

AU - Abeykoon, Jithma P.

AU - Forma-Borst, Jelske

AU - Steenwijk, Eline C.

AU - Feijen, Elizabeth A. M.

AU - Teepen, Jop C.

AU - Bennani, N. Nora

AU - Schram, Susan M.

AU - Shah, Mithun V.

AU - Davidge-Pitts, Caroline

AU - Koster, Matthew J.

AU - Ryu, Jay H.

AU - Vassallo, Robert

AU - Tobin, W. Oliver

AU - Young, Jason R.

AU - Dasari, Surendra

AU - Rech, Karen

AU - Ravindran, Aishwarya

AU - Cleven, Arjen H. G.

AU - Verdijk, Robert M.

AU - van Noesel, Carel J. M.

AU - Balgobind, Brian V.

AU - Bouma, Gerrit Joan

AU - Saeed, Peerooz

AU - Bramer, Jos A. M.

AU - de Groen, Ruben A. L.

AU - Vermaat, Joost S. P.

AU - van de Sande, Michiel A. J.

AU - Smit, Egbert F.

AU - Langerak, Anton W.

AU - van Wezel, Tom

AU - Tonino, Sanne H.

AU - van den Bos, Cor

AU - van Laar, Jan A. M.

AU - Go, Ronald S.

AU - Goyal, Gaurav

AU - van Halteren, Astrid G. S.

N1 - Funding Information: The authors thank the molecular diagnostics staff of the Department of Pathology of Leiden University Medical Center, as well as Michelle van der Klift, Fleur de Groot, Patty Jansen, and Karoly Szuhai for their help with genetic analyses. Sofie Breuking is acknowledged for prior work on the systematic review. The authors also thank Wichor Bramer from the Erasmus MC Medical Library for developing and updating the search strategies for the systematic review. Figure 1G-H was made with BioRender.com software. This study was supported by grants from Stichting 1000 Kaarsjes voor Juultje to A.G.S.v.H. the University of Iowa/Mayo Clinic Lymphoma SPORE P50 CA97274 to G.G. and J.P.A. and the Walter B. Frommeyer, Jr, Fellowship Award in Investigative Medicine, University of Alabama at Birmingham, to G.G. P.G.K. received an MD/PhD grant from Leiden University Medical Center. Contribution: C.v.d.B. J.A.M.v.L. R.S.G. G.G. and A.G.S.v.H. conceived the study; A.A.A.-M. P.G.K. T.C.E.Z. and J.P.A. collected clinical data; P.G.K. J.F.-B. E.C.S. S.D. R.A.L.d.G. A.W.L. T.v.W. and A.G.S.v.H. performed additional molecular genetic analyses outside routine diagnostics; P.G.K. analyzed the combined clinicogenomic data set and drafted the (supplemental) figures and tables; T.C.E.Z. performed the systematic review and meta-analysis, with P.G.K. as second assessor; E.A.M.F. supervised the systematic review and statistical analyses; J.C.T. helped with calculating standardized incidence ratios for second cancers; A.A.A.-M. P.G.K. T.C.E.Z. R.S.G. G.G. and A.G.S.v.H. drafted the manuscript; A.A.A.-M. J.P.A. N.N.B. S.M.S. M.V.S. C.D.-P. M.J.K. J.H.R. R.V. W.O.T. J.R.Y. K.R. A.R. A.H.G.C. R.M.V. C.J.M.v.N. B.V.B. G.J.B. P.S. J.A.M.B. J.S.P.V. M.A.J.v.d.S. E.F.S. S.H.T. C.v.d.B. J.A.M.v.L. R.S.G. and G.G. were involved in clinical care for included patients; and all authors critically reviewed and approved the manuscript. Funding Information: This study was supported by grants from Stichting 1000 Kaarsjes voor Juultje to A.G.S.v.H., the University of Iowa / Mayo Clinic Lymphoma SPORE P50 CA97274 to G.G. and J.P.A., and the Walter B. Frommeyer, Jr, Fellowship Award in Investigative Medicine, University of Alabama at Birmingham , to G.G. P.G.K. received an MD/PhD grant from Leiden University Medical Center . Publisher Copyright: © 2023 The American Society of Hematology

PY - 2023/11/2

Y1 - 2023/11/2

N2 - In this retrospective study, BRAF mutation status did not correlate with disease extent or (event-free) survival in 156 adults with Langerhans cell histiocytosis. BRAFV600E was associated with an increased incidence of second malignancies, often comprising hematological cancers, which may be clonally related.

AB - In this retrospective study, BRAF mutation status did not correlate with disease extent or (event-free) survival in 156 adults with Langerhans cell histiocytosis. BRAFV600E was associated with an increased incidence of second malignancies, often comprising hematological cancers, which may be clonally related.

UR - http://www.scopus.com/inward/record.url?scp=85173133493&partnerID=8YFLogxK

U2 - https://doi.org/10.1182/blood.2023021212

DO - https://doi.org/10.1182/blood.2023021212

M3 - Article

C2 - 37595284

SN - 0006-4971

VL - 142

SP - 1570

EP - 1575

JO - Blood

JF - Blood

IS - 18

ER -

BRAFV600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis

Abstract

Access to Document

Other files and links

Cite this