Middellangetermijnoverleving na open versus robotgeassisteerde radicale cystectomie in Nederland: resultaten van de ‘SNAPSHOT’ cystectomie

Translated title of the contribution: Intermediate term survival following open versus robot-assisted radical cystectomy in the Netherlands: results of the Cystectomie SNAPSHOT study

Noor van Ginkel, André N. Vis, Joost L. Boormans, Henk G. van der Poel, Deric K. E. van der Schoot, Katja K. H. Aben, Tom J. N. Hermans, Dennie Meijer, Jens Voortman, Tom J. H. Arends, Peter J. Ausems, Dorine Baselmans, Christian P. A. M. Berger, Anne-Claire Berrens, Henry Bickerstaffe, Siebe D. Bos, Marlene Braam, K. Tim Buddingh, Sebastiaan Claus, Karen DekkerThomas van Doeveren, Sarah M. H. Einerhand, Laurent M. C. Laurent Fossion, Florentien J. Hinsenveld, Erik J. van Gennep, Lorena A. Grondhuis Palacios, Mandy M. Hobijn, Suzanne H. van Huystee, Martinique Jaspers-Valentijn, O. Sjoerd Klaver, Evert L. Koldewijn, Linn Korsten, Anne Lenting, Koen J. Lentjes, Henk B. Luiting, Saskia van der Meer, Laura Mertens, Jakko A. Nieuwenhuijzen, M. Arjen Noordzij, Ronald I. Nooter, Marije Notenboom, Robert J. A. Oomen, Joep G. H. van Roermund, Judith de Rooij, Hossain Roshani, Bart P. Schrier, Michelle A. van der Slot, D. M. Rik Somford, Piter-Jan Stelwagen, Aukje M. A. Stroux, Alwine van der West, Bart P. Wijsman, Willemijn A. K. M. Windt, Paul van Zanten, Sytse C. van Beek

Research output: Contribution to journalArticleProfessional

Abstract

There is insufficient knowledge on intermediate-term survival of non-metastatic muscle-invasive bladder cancer (MIBC) after open (ORC) versus robot-assisted (RARC) cystectomy, with or without neo-adjuvant chemotherapy (NAC). This retrospective study was performed in 19 Dutch hospitals between 2012 and 2015 to assess the five-year survival after both interventions and the influence of NAC. Out of 1,534 cT1-4N0-1-patients, 1,086 patients were treated with ORC and 389 with RARC. The 5‑year survival rate after ORC was 51% (95% CI 47–53) versus 58% after RARC (95% CI 52–63), hazard ratio 1.00 (95% CI 0.84–1.20) after multivariable analysis. 226 of 965 cT2-4aN0 patients were treated with NAC. More patients had ypT0 after NAC than after no NAC (31% vs 15%; p < 0.01). The best five-year survival was in patients with ypT0 after NAC (89%; 95% CI 81–97). This study shows similar five-year survival of MIBC patients treated with ORC or RARC and shows that the best survival was after NAC.

Translated title of the contributionIntermediate term survival following open versus robot-assisted radical cystectomy in the Netherlands: results of the Cystectomie SNAPSHOT study
Original languageDutch
Pages (from-to)164-175
Number of pages12
JournalTijdschrift voor Urologie
Volume13
Issue number8
Early online date2023
DOIs
Publication statusPublished - Dec 2023

Keywords

  • chemotherapy
  • muscle-invasive bladdercancer
  • prognosis
  • radical cystectomy

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