Abstract
6-Thioguanine is used as an escape thiopurine for treating inflammatory bowel disease patients intolerant or refractory to azathioprine, 6-mercaptopurine or methotrexate. Case reports show conflicting data on the use of 6-thioguanine throughout pregnancy. The administration of the standard thiopurines is believed to be relatively safe. We describe two patients with Crohn's disease treated with low-dose 6-thioguanine during all trimesters of their pregnancies. The pregnancies resulted in two healthy infants: without congenital abnormalities, laboratory signs of myelosuppression or hepatocellular injury. Thiopurine metabolites were measured in mother and infant. Significantly lower levels of 6-thioguaninenucleotides were found in the erythrocytes of the infant compared to the mother ( ratio 1: 12). Further studies are needed to determine the clinical importance of thiopurine metabolite measurements during pregnancy in mother and child
Original language | English |
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Pages (from-to) | 1374-1377 |
Journal | Scandinavian journal of gastroenterology |
Volume | 40 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2005 |