TY - JOUR
T1 - Sex-specific effects of prenatal undernutrition on resting-state functional connectivity in the human brain at age 68
AU - Boots, Amber
AU - Thomason, Moriah E.
AU - Espinoza-Heredia, Claudia
AU - Pruitt, Patrick J.
AU - Damoiseaux, Jessica S.
AU - Roseboom, Tessa J.
AU - de Rooij, Susanne R.
N1 - Funding Information: This study was funded by a NWO Aspasia grant (015014039) awarded to SR de Rooij and supported by the European Commission Horizon 2020, project LongITools (874739). The funding sources had no involvement in study design, data collection, analysis, interpretation of data, writing and submission. Publisher Copyright: © 2022
PY - 2022/4/1
Y1 - 2022/4/1
N2 - Prenatal nutrition may significantly impact brain aging. Results from the Dutch Famine Birth Cohort indicated that prenatal undernutrition is negatively associated with cognition, brain volumes, perfusion and structural brain aging in late life, predominantly in men. This study investigates the association between prenatal undernutrition and late-life functional brain network connectivity. In an exploratory resting-state functional magnetic resonance imaging study of 112 participants from the Dutch Famine Birth Cohort, we investigated whether the within- and between-network functional connectivity of the default mode network, salience network and central executive network differ at age 68 in men (N = 49) and women (N = 63) either exposed or unexposed to undernutrition in early gestation. Additionally, we explored sex-specific effects. Compared to unexposed participants, exposed participants revealed multiple clusters of different functional connectivity within and between the three networks studied. Sex-specific analyses suggested a pattern of network desegregation fitting with brain aging in men and a more diffuse pattern of group differences in women. This study demonstrates that associations between prenatal undernutrition and brain network functional connectivity extend late into life.
AB - Prenatal nutrition may significantly impact brain aging. Results from the Dutch Famine Birth Cohort indicated that prenatal undernutrition is negatively associated with cognition, brain volumes, perfusion and structural brain aging in late life, predominantly in men. This study investigates the association between prenatal undernutrition and late-life functional brain network connectivity. In an exploratory resting-state functional magnetic resonance imaging study of 112 participants from the Dutch Famine Birth Cohort, we investigated whether the within- and between-network functional connectivity of the default mode network, salience network and central executive network differ at age 68 in men (N = 49) and women (N = 63) either exposed or unexposed to undernutrition in early gestation. Additionally, we explored sex-specific effects. Compared to unexposed participants, exposed participants revealed multiple clusters of different functional connectivity within and between the three networks studied. Sex-specific analyses suggested a pattern of network desegregation fitting with brain aging in men and a more diffuse pattern of group differences in women. This study demonstrates that associations between prenatal undernutrition and brain network functional connectivity extend late into life.
KW - Brain aging
KW - Brain development
KW - Fetal programming
KW - Prenatal undernutrition
KW - fMRI
UR - http://www.scopus.com/inward/record.url?scp=85124425831&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.neurobiolaging.2022.01.003
DO - https://doi.org/10.1016/j.neurobiolaging.2022.01.003
M3 - Article
C2 - 35151035
SN - 0197-4580
VL - 112
SP - 129
EP - 138
JO - Neurobiology of aging
JF - Neurobiology of aging
ER -