TY - JOUR
T1 - A big data approach to myocyte membrane analysis
T2 - 44th Computing in Cardiology Conference, CinC 2017
AU - Ledezma, Carlos A.
AU - Kappler, Benjamin
AU - Meijborg, Veronique
AU - Boukens, Bas
AU - Stijnen, Marco
AU - Tan, P. J.
AU - Díaz-Zuccarini, Vanessa
N1 - Funding Information: This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 642612, VPH-CaSE (www.vph-case.eu) Publisher Copyright: © 2017 IEEE Computer Society. All rights reserved.
PY - 2017
Y1 - 2017
N2 - Experimentally-calibrated populations of models (ePoMs) allow to elucidate the trends hidden behind large amounts of data, but they have never been used as a means to monitor the temporal evolution of a heart's electrical activity. This work aimed at using ePoMs to understand the cell membrane anomalies that lead to heart failure. A population of the Tusscher-Noble-Noble-Panfilov model was calibrated to the activation-recovery intervals measured from epicardial electrograms acquired during a Physio-heart experiment. A Mann-Whitney-Wilcoxon U-test was performed on the statistical distributions of the calibrated parameters, at different time points during the experiment, to elucidate the physiology changes that would have led to the resulting ePoMs. The methodology developed in this paper could detect the specific pathological ion dynamics responsible for the abnormal electrical behavior observed during the experiment. Furthermore, the analysis of the electrical activities was capable of detection of pathologies at an earlier stage when compared to the analysis of the cardiac output alone. The use of big data analytics proved to be more effective than the traditional signal analysis approach in predicting heart failure; additionally, this approach accounts for variabilities in both the healthy and the pathological conditions.
AB - Experimentally-calibrated populations of models (ePoMs) allow to elucidate the trends hidden behind large amounts of data, but they have never been used as a means to monitor the temporal evolution of a heart's electrical activity. This work aimed at using ePoMs to understand the cell membrane anomalies that lead to heart failure. A population of the Tusscher-Noble-Noble-Panfilov model was calibrated to the activation-recovery intervals measured from epicardial electrograms acquired during a Physio-heart experiment. A Mann-Whitney-Wilcoxon U-test was performed on the statistical distributions of the calibrated parameters, at different time points during the experiment, to elucidate the physiology changes that would have led to the resulting ePoMs. The methodology developed in this paper could detect the specific pathological ion dynamics responsible for the abnormal electrical behavior observed during the experiment. Furthermore, the analysis of the electrical activities was capable of detection of pathologies at an earlier stage when compared to the analysis of the cardiac output alone. The use of big data analytics proved to be more effective than the traditional signal analysis approach in predicting heart failure; additionally, this approach accounts for variabilities in both the healthy and the pathological conditions.
UR - http://www.scopus.com/inward/record.url?scp=85045095009&partnerID=8YFLogxK
U2 - https://doi.org/10.22489/CinC.2017.313-264
DO - https://doi.org/10.22489/CinC.2017.313-264
M3 - Article
SN - 2325-8861
VL - 44
SP - 1
EP - 4
JO - Computing in Cardiology
JF - Computing in Cardiology
Y2 - 24 September 2017 through 27 September 2017
ER -