TY - GEN
T1 - A clinical probe for combined Raman spectroscopy-optical coherence tomography (RS-OCT) of the skin cancers
AU - Patil, Chetan A.
AU - Krishnamoorthi, Harish
AU - Ellis, Darrel L.
AU - Van Leeuwen, Ton G.
AU - Mahadevan-Jansen, Anita
PY - 2010
Y1 - 2010
N2 - Skin cancer is the most commonly occurring cancer, with incidence rates rising annually. Realizing favorable outcomes requires early diagnosis, for which the current standard is biopsy followed by histopathology. This process can be invasive, subjective, time consuming, and costly. Optical techniques, including Optical Coherence Tomography (OCT) and Raman Spectroscopy (RS), have been developed to perform non-invasive characterization of skin lesions, however neither is without limitation. Here, we demonstrate a clinical instrument for morphological and biochemical characterization of skin cancers with combined RS-OCT. The portable instrument utilizes independent RS and OCT system backbones, and is integrated in a common clinical probe. The potential of the probe for cancer diagnosis is demonstrated on malignant and non-malignant lesions.
AB - Skin cancer is the most commonly occurring cancer, with incidence rates rising annually. Realizing favorable outcomes requires early diagnosis, for which the current standard is biopsy followed by histopathology. This process can be invasive, subjective, time consuming, and costly. Optical techniques, including Optical Coherence Tomography (OCT) and Raman Spectroscopy (RS), have been developed to perform non-invasive characterization of skin lesions, however neither is without limitation. Here, we demonstrate a clinical instrument for morphological and biochemical characterization of skin cancers with combined RS-OCT. The portable instrument utilizes independent RS and OCT system backbones, and is integrated in a common clinical probe. The potential of the probe for cancer diagnosis is demonstrated on malignant and non-malignant lesions.
KW - Basal Cell Carcinoma
KW - Optical Coherence Tomography
KW - Raman Spectroscopy
KW - Skin
KW - Skin Cancer
UR - http://www.scopus.com/inward/record.url?scp=79751482900&partnerID=8YFLogxK
U2 - https://doi.org/10.1117/12.843708
DO - https://doi.org/10.1117/12.843708
M3 - Conference contribution
SN - 9780819479440
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Photonic Therapeutics and Diagnostics VI
T2 - Photonic Therapeutics and Diagnostics VI
Y2 - 23 January 2010 through 25 January 2010
ER -