TY - JOUR
T1 - A common biological basis of obesity and nicotine addiction
AU - Thorgeirsson, T.E.
AU - Gudbjartsson, D.F.
AU - Sulem, P.
AU - Besenbacher, S.
AU - Styrkarsdottir, U.
AU - Thorleifsson, G.
AU - Walters, G.B.
AU - Furberg, H.
AU - Sullivan, P.F.
AU - Marchini, J.
AU - McCarthy, M.I.
AU - Steinthorsdottir, V.
AU - Thorsteinsdottir, U.
AU - Stefansson, K.
AU - Posthuma, D.
N1 - TAG Consortium; Oxford-GSK Consortium; ENGAGE consortium,
PY - 2013
Y1 - 2013
N2 - Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism. However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked per day (CPD) in an Icelandic sample (N=34 216 smokers). Combined according to their effect on BMI, the SNPs correlate with both SI (r=0.019, P=0.00054) and CPD (r=0.032, P=8.0 × 10
AB - Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism. However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked per day (CPD) in an Icelandic sample (N=34 216 smokers). Combined according to their effect on BMI, the SNPs correlate with both SI (r=0.019, P=0.00054) and CPD (r=0.032, P=8.0 × 10
U2 - https://doi.org/10.1038/tp.2013.81
DO - https://doi.org/10.1038/tp.2013.81
M3 - Article
C2 - 24084939
SN - 2158-3188
VL - 3
SP - e308
JO - Translational Psychiatry
JF - Translational Psychiatry
M1 - e308
ER -