A common biological basis of obesity and nicotine addiction

T.E. Thorgeirsson; D.F. Gudbjartsson; P. Sulem; S. Besenbacher; U. Styrkarsdottir; G. Thorleifsson; G.B. Walters; H. Furberg; P.F. Sullivan; J. Marchini; M.I. McCarthy; V. Steinthorsdottir; U. Thorsteinsdottir; K. Stefansson; D. Posthuma

doi:https://doi.org/10.1038/tp.2013.81

A common biological basis of obesity and nicotine addiction

T.E. Thorgeirsson, D.F. Gudbjartsson, P. Sulem, S. Besenbacher, U. Styrkarsdottir, G. Thorleifsson, G.B. Walters, H. Furberg, P.F. Sullivan, J. Marchini, M.I. McCarthy, V. Steinthorsdottir, U. Thorsteinsdottir, K. Stefansson, D. Posthuma

Human Genetics (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

43 Citations (Scopus)

Abstract

Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism. However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked per day (CPD) in an Icelandic sample (N=34 216 smokers). Combined according to their effect on BMI, the SNPs correlate with both SI (r=0.019, P=0.00054) and CPD (r=0.032, P=8.0 × 10

Original language	English
Article number	e308
Pages (from-to)	e308
Journal	Translational Psychiatry
Volume	3
Early online date	1 Oct 2013
DOIs	https://doi.org/10.1038/tp.2013.81
Publication status	Published - 2013

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https://doi.org/10.1038/tp.2013.81

Cite this

Thorgeirsson, T. E., Gudbjartsson, D. F., Sulem, P., Besenbacher, S., Styrkarsdottir, U., Thorleifsson, G., Walters, G. B., Furberg, H., Sullivan, P. F., Marchini, J., McCarthy, M. I., Steinthorsdottir, V., Thorsteinsdottir, U., Stefansson, K., & Posthuma, D. (2013). A common biological basis of obesity and nicotine addiction. Translational Psychiatry, 3, e308. Article e308. https://doi.org/10.1038/tp.2013.81

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title = "A common biological basis of obesity and nicotine addiction",

abstract = "Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism. However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked per day (CPD) in an Icelandic sample (N=34 216 smokers). Combined according to their effect on BMI, the SNPs correlate with both SI (r=0.019, P=0.00054) and CPD (r=0.032, P=8.0 × 10",

author = "T.E. Thorgeirsson and D.F. Gudbjartsson and P. Sulem and S. Besenbacher and U. Styrkarsdottir and G. Thorleifsson and G.B. Walters and H. Furberg and P.F. Sullivan and J. Marchini and M.I. McCarthy and V. Steinthorsdottir and U. Thorsteinsdottir and K. Stefansson and D. Posthuma",

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Thorgeirsson, TE, Gudbjartsson, DF, Sulem, P, Besenbacher, S, Styrkarsdottir, U, Thorleifsson, G, Walters, GB, Furberg, H, Sullivan, PF, Marchini, J, McCarthy, MI, Steinthorsdottir, V, Thorsteinsdottir, U, Stefansson, K & Posthuma, D 2013, 'A common biological basis of obesity and nicotine addiction', Translational Psychiatry, vol. 3, e308, pp. e308. https://doi.org/10.1038/tp.2013.81

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AU - Thorgeirsson, T.E.

AU - Gudbjartsson, D.F.

AU - Sulem, P.

AU - Besenbacher, S.

AU - Styrkarsdottir, U.

AU - Thorleifsson, G.

AU - Walters, G.B.

AU - Furberg, H.

AU - Sullivan, P.F.

AU - Marchini, J.

AU - McCarthy, M.I.

AU - Steinthorsdottir, V.

AU - Thorsteinsdottir, U.

AU - Stefansson, K.

AU - Posthuma, D.

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