@article{9b8d2bbdf28c437ba5c97ff168785e50,
title = "A companion to the preclinical common data elements for genomics, transcriptomics and epigenomics data in rodent epilepsy models.: A Report of the TASK3-WG4 Omics Working Group of the ILAE/AES Joint Translational Task Force",
abstract = "The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. The aim of the CDEs is to improve the standardization of experimental designs across a range of epilepsy research related methods. Here, we have generated CDE tables with key parameters and case report forms (CRFs) containing the essential contents of the study protocols for genomics, transcriptomics and epigenomics in rodent models of epilepsy, with a specific focus on adult rats and mice. We discuss the important elements that need to be considered for genomics, transcriptomics and epigenomics methodologies, providing a rationale for the parameters that should be collected. This is the first in a two-part series of omics papers with the second instalment to cover proteomics, lipidomics, and metabolomics in adult rodents.",
keywords = "common data elements, mouse, omic data processing, preclinical, rat",
author = "{van Vliet}, E.A. and M.S. Hildebrand and J.D. Mills and G.P. Brennan and T. Eid and S.A. Masino and V. Whittemore and L. Bindila and K.K. Wang and M. Patel and P. Perucca and C.A. Reid",
note = "Funding Information: This report was written by experts selected by the International League Against Epilepsy (ILAE) and the American Epilepsy Society (AES) and was approved for publication by the ILAE and the AES. Opinions expressed by the authors, however, do not represent the policy or position of the ILAE or the AES. We are also grateful to the AES and ILAE for their financial support of the activities of TASK3 working groups. The authors are grateful to Dr Lauren Harte‐Hargrove, director of research at CURE Epilepsy, and Victoria A. Marciniak from the Cardinal Gibbons High School at Raleigh North Carolina, for their expert work in converting the CRFs to the CDE spreadsheets. Publisher Copyright: {\textcopyright} 2022 The Authors. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.",
year = "2022",
month = aug,
day = "11",
doi = "https://doi.org/10.1002/epi4.12640",
language = "English",
journal = "Epilepsia Open",
issn = "2470-9239",
publisher = "Wiley-Blackwell Publishing Ltd",
}