TY - JOUR
T1 - A companion to the preclinical common data elements for proteomics, lipidomics, and metabolomics data in rodent epilepsy models. A report of the TASK3-WG4 omics working group of the ILAE/AES joint translational TASK force
AU - Bindila, Laura
AU - Eid, Tore
AU - Mills, James D.
AU - Hildebrand, Michael S.
AU - Brennan, Gary P.
AU - Masino, Susan A.
AU - Whittemore, Vicky
AU - Perucca, Piero
AU - Reid, Christopher A.
AU - Patel, Manisha
AU - Wang, Kevin K.
AU - van Vliet, Erwin A.
N1 - Funding Information: We acknowledge the American Epilepsy Society (AES) and International League Against Epilepsy (ILAE) for sponsoring the activities of the ILAE/AES Joint Translational Task Force. This report was written by experts selected by ILAE and AES and was approved for publication by the ILAE and the AES. Opinions expressed by the authors, however, do not represent the policy or position of the ILAE or the AES. We are also grateful to the AES and ILAE for their financial support of the activities of TASK3 working groups. . The authors are grateful to Dr. Lauren Harte‐Hargrove, Director of Research at CURE Epilepsy, and Victoria A. Marciniak from the Cardinal Gibbons High School at Raleigh North Carolina, for their expert work in converting the CRFs to the CDE spreadsheets Publisher Copyright: © 2022 The Authors. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.
PY - 2022/11/13
Y1 - 2022/11/13
N2 - The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. This is the second in a two-part series of omics papers, with the other including genomics, transcriptomics, and epigenomics. The aim of the CDEs was to improve the standardization of experimental designs across a range of epilepsy research-related methods. We have generated CDE tables with key parameters and case report forms (CRFs) containing the essential contents of the study protocols for proteomics, lipidomics, and metabolomics of samples from rodent models and people with epilepsy. We discuss the important elements that need to be considered for the proteomics, lipidomics, and metabolomics methodologies, providing a rationale for the parameters that should be documented.
AB - The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. This is the second in a two-part series of omics papers, with the other including genomics, transcriptomics, and epigenomics. The aim of the CDEs was to improve the standardization of experimental designs across a range of epilepsy research-related methods. We have generated CDE tables with key parameters and case report forms (CRFs) containing the essential contents of the study protocols for proteomics, lipidomics, and metabolomics of samples from rodent models and people with epilepsy. We discuss the important elements that need to be considered for the proteomics, lipidomics, and metabolomics methodologies, providing a rationale for the parameters that should be documented.
KW - case report form
KW - lipidome
KW - metabolome
KW - omic data processing
KW - preclinical
KW - proteome
KW - rodent
UR - http://www.scopus.com/inward/record.url?scp=85142015778&partnerID=8YFLogxK
UR - https://pure.uva.nl/ws/files/116160371/ep1412662_sup_0001_1._cde_chart_sample_collection_and_storage_for_proteomics_lipidomics_metabolomics.xlsx
UR - https://pure.uva.nl/ws/files/116160373/ep1412662_sup_0002_1._crf_module_sample_collection_and_storage_for_proteomics_lipidomics_metabolomics_sup.docx
UR - https://pure.uva.nl/ws/files/116160375/ep1412662_sup_0003_2._cde_chart_proteomics.xlsx
UR - https://pure.uva.nl/ws/files/116160377/ep1412662_sup_0004_2._crf_module_proteomics_sup.docx
UR - https://pure.uva.nl/ws/files/116160379/ep1412662_sup_0005_3._cde_chart_lipidomics_metabolomics.xlsx
UR - https://pure.uva.nl/ws/files/116160381/ep1412662_sup_0006_3._crf_module_lipidomics_metabolomics_sup.docx
UR - https://pure.uva.nl/ws/files/116160383/ep1412662_sup_0007_4._cde_chart_data_management.xlsx
UR - https://pure.uva.nl/ws/files/116160385/ep1412662_sup_0008_4._crf_module_data_management_sup.docx
U2 - https://doi.org/10.1002/epi4.12662
DO - https://doi.org/10.1002/epi4.12662
M3 - Article
C2 - 36259125
SN - 2470-9239
JO - Epilepsia Open
JF - Epilepsia Open
ER -