TY - JOUR
T1 - A focus on the association of Apol1 with kidney disease in children
AU - Ekulu, Pepe M.
AU - Nkoy, Agathe B.
AU - Adebayo, Oyindamola C.
AU - Kazadi, Orly K.
AU - Aloni, Michel N.
AU - Arcolino, Fanny O.
AU - Ngiyulu, Rene M.
AU - Gini, Jean Lambert E.
AU - Lepira, François B.
AU - Van den Heuvel, Lamberthus P.
AU - Levtchenko, Elena N.
N1 - Publisher Copyright: © 2020, IPNA.
PY - 2021/4
Y1 - 2021/4
N2 - Individuals of African origin have an increased risk of developing various progressive chronic kidney diseases (CKD). This risk has been attributed to genetic variants (G1, G2) in apolipoprotein-L1 (APOL1) gene. In the pediatric population, especially in children affected by sickle cell disease (SCD), by human immunodeficiency virus (HIV), or with various glomerular diseases, APOL1 risk variants have been associated with the development of hypertension, albuminuria, and more rapid decline of kidney function. The present review focuses on existing APOL1-related epidemiological data in children with CKD. It also includes data from studies addressing racial disparities in CKD, the APOL1-related innate immunity, and the relationship between APOL1 and CKD and pathogenic pathways mediating APOL1-related kidney injury.
AB - Individuals of African origin have an increased risk of developing various progressive chronic kidney diseases (CKD). This risk has been attributed to genetic variants (G1, G2) in apolipoprotein-L1 (APOL1) gene. In the pediatric population, especially in children affected by sickle cell disease (SCD), by human immunodeficiency virus (HIV), or with various glomerular diseases, APOL1 risk variants have been associated with the development of hypertension, albuminuria, and more rapid decline of kidney function. The present review focuses on existing APOL1-related epidemiological data in children with CKD. It also includes data from studies addressing racial disparities in CKD, the APOL1-related innate immunity, and the relationship between APOL1 and CKD and pathogenic pathways mediating APOL1-related kidney injury.
KW - APOL1
KW - Children
KW - Chronic kidney disease
KW - Genetics
KW - HIV-associated nephropathy
KW - Sickle cell disease
UR - http://www.scopus.com/inward/record.url?scp=85083066893&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s00467-020-04553-z
DO - https://doi.org/10.1007/s00467-020-04553-z
M3 - Review article
C2 - 32253519
SN - 0931-041X
VL - 36
SP - 777
EP - 788
JO - Pediatric Nephrology
JF - Pediatric Nephrology
IS - 4
ER -