TY - JOUR
T1 - A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
AU - AUTHOR GROUP
AU - Peden, John F.
AU - Hopewell, Jemma C.
AU - Saleheen, Danish
AU - Chambers, John C.
AU - Hager, Jorg
AU - Soranzo, Nicole
AU - Collins, Rory
AU - Danesh, John
AU - Elliott, Paul
AU - Farrall, Martin
AU - Stirrups, Kathy
AU - Zhang, Weihua
AU - Hamsten, Anders
AU - Parish, Sarah
AU - Lathrop, Mark
AU - Watkins, Hugh
AU - Clarke, Robert
AU - Deloukas, Panos
AU - Kooner, Jaspal S.
AU - Goel, Anuj
AU - Ongen, Halit
AU - Strawbridge, Rona J.
AU - Heath, Simon
AU - Mälarstig, Anders
AU - Helgadottir, Anna
AU - Öhrvik, John
AU - Murtaza, Muhammed
AU - Potter, Simon
AU - Hunt, Sarah E.
AU - Delepine, Marc
AU - Jalilzadeh, Shapour
AU - Axelsson, Tomas
AU - Syvanen, Ann-Christine
AU - Gwilliam, Rhian
AU - Bumpstead, Suzannah
AU - Gray, Emma
AU - Edkins, Sarah
AU - Folkersen, Lasse
AU - Kyriakou, Theodosios
AU - Franco-Cereceda, Anders
AU - Gabrielsen, Anders
AU - Seedorf, Udo
AU - Eriksson, Per
AU - Offer, Alison
AU - Bowman, Louise
AU - Sleight, Peter
AU - Armitage, Jane
AU - Peto, Richard
AU - Kastelein, John J. P.
AU - Trip, Mieke D.
PY - 2011
Y1 - 2011
N2 - Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD)¹⁻⁷, a modest number considering the apparent heritability of CAD⁸. All of these variants have been discovered in European populations. We report a meta-analysis of four large genome-wide association studies of CAD, with ∼575,000 genotyped SNPs in a discovery dataset comprising 15,420 individuals with CAD (cases) (8,424 Europeans and 6,996 South Asians) and 15,062 controls. There was little evidence for ancestry-specific associations, supporting the use of combined analyses. Replication in an independent sample of 21,408 cases and 19,185 controls identified five loci newly associated with CAD (P < 5 × 10⁻⁸ in the combined discovery and replication analysis): LIPA on 10q23, PDGFD on 11q22, ADAMTS7-MORF4L1 on 15q25, a gene rich locus on 7q22 and KIAA1462 on 10p11. The CAD-associated SNP in the PDGFD locus showed tissue-specific cis expression quantitative trait locus effects. These findings implicate new pathways for CAD susceptibility
AB - Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD)¹⁻⁷, a modest number considering the apparent heritability of CAD⁸. All of these variants have been discovered in European populations. We report a meta-analysis of four large genome-wide association studies of CAD, with ∼575,000 genotyped SNPs in a discovery dataset comprising 15,420 individuals with CAD (cases) (8,424 Europeans and 6,996 South Asians) and 15,062 controls. There was little evidence for ancestry-specific associations, supporting the use of combined analyses. Replication in an independent sample of 21,408 cases and 19,185 controls identified five loci newly associated with CAD (P < 5 × 10⁻⁸ in the combined discovery and replication analysis): LIPA on 10q23, PDGFD on 11q22, ADAMTS7-MORF4L1 on 15q25, a gene rich locus on 7q22 and KIAA1462 on 10p11. The CAD-associated SNP in the PDGFD locus showed tissue-specific cis expression quantitative trait locus effects. These findings implicate new pathways for CAD susceptibility
U2 - https://doi.org/10.1038/ng.782
DO - https://doi.org/10.1038/ng.782
M3 - Article
C2 - 21378988
SN - 1061-4036
VL - 43
SP - 339
EP - 344
JO - Nature Genetics
JF - Nature Genetics
IS - 4
ER -