A Genome-Wide Meta-Analysis of Association Studies of Cloninger’s Temperament Scales.

S.K. Service; K.J.H. Verweij; J. Lahti; E. Congdon; J. Ekelund; M. Hintsanen; K. Räikkönen; T. Lehtimäki; M. Kähönen; E. Widen; A. Taanila; J. Veijola; A.C. Heath; P.A.F. Madden; G.W. Montgomery; C. Sabatti; M.R. Järvelin; A. Palotie; O. Raitakari; J. Viikari; N.G. Martin; J.G. Eriksson; L. Keltikangas-Järvinen; N.R. Wray; N.B. Freimer

doi:https://doi.org/10.1038/tp.2012.37

A Genome-Wide Meta-Analysis of Association Studies of Cloninger’s Temperament Scales.

S.K. Service, K.J.H. Verweij, J. Lahti, E. Congdon, J. Ekelund, M. Hintsanen, K. Räikkönen, T. Lehtimäki, M. Kähönen, E. Widen, A. Taanila, J. Veijola, A.C. Heath, P.A.F. Madden, G.W. Montgomery, C. Sabatti, M.R. Järvelin, A. Palotie, O. Raitakari, J. ViikariN.G. Martin, J.G. Eriksson, L. Keltikangas-Järvinen, N.R. Wray, N.B. Freimer

Amsterdam UMC

Research output: Contribution to journal › Article › Academic › peer-review

56 Citations (Scopus)

Abstract

Temperament has a strongly heritable component, yet multiple independent genome-wide studies have failed to identify significant genetic associations. We have assembled the largest sample to date of persons with genome-wide genotype data, who have been assessed with Cloninger's Temperament and Character Inventory. Sum scores for novelty seeking, harm avoidance, reward dependence and persistence have been measured in over 11 000 persons collected in four different cohorts. Our study had >80% power to identify genome-wide significant loci (P<1.25 × 10

Original language	English
Article number	e116
Pages (from-to)	e116
Journal	Translational Psychiatry
Volume	2
Issue number	5
DOIs	https://doi.org/10.1038/tp.2012.37
Publication status	Published - 2012

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Service, S. K., Verweij, K. J. H., Lahti, J., Congdon, E., Ekelund, J., Hintsanen, M., Räikkönen, K., Lehtimäki, T., Kähönen, M., Widen, E., Taanila, A., Veijola, J., Heath, A. C., Madden, P. A. F., Montgomery, G. W., Sabatti, C., Järvelin, M. R., Palotie, A., Raitakari, O., ... Freimer, N. B. (2012). A Genome-Wide Meta-Analysis of Association Studies of Cloninger’s Temperament Scales. Translational Psychiatry, 2(5), e116. Article e116. https://doi.org/10.1038/tp.2012.37

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title = "A Genome-Wide Meta-Analysis of Association Studies of Cloninger{\textquoteright}s Temperament Scales.",

abstract = "Temperament has a strongly heritable component, yet multiple independent genome-wide studies have failed to identify significant genetic associations. We have assembled the largest sample to date of persons with genome-wide genotype data, who have been assessed with Cloninger's Temperament and Character Inventory. Sum scores for novelty seeking, harm avoidance, reward dependence and persistence have been measured in over 11 000 persons collected in four different cohorts. Our study had >80% power to identify genome-wide significant loci (P<1.25 × 10",

author = "S.K. Service and K.J.H. Verweij and J. Lahti and E. Congdon and J. Ekelund and M. Hintsanen and K. R{\"a}ikk{\"o}nen and T. Lehtim{\"a}ki and M. K{\"a}h{\"o}nen and E. Widen and A. Taanila and J. Veijola and A.C. Heath and P.A.F. Madden and G.W. Montgomery and C. Sabatti and M.R. J{\"a}rvelin and A. Palotie and O. Raitakari and J. Viikari and N.G. Martin and J.G. Eriksson and L. Keltikangas-J{\"a}rvinen and N.R. Wray and N.B. Freimer",

year = "2012",

doi = "https://doi.org/10.1038/tp.2012.37",

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Service, SK, Verweij, KJH, Lahti, J, Congdon, E, Ekelund, J, Hintsanen, M, Räikkönen, K, Lehtimäki, T, Kähönen, M, Widen, E, Taanila, A, Veijola, J, Heath, AC, Madden, PAF, Montgomery, GW, Sabatti, C, Järvelin, MR, Palotie, A, Raitakari, O, Viikari, J, Martin, NG, Eriksson, JG, Keltikangas-Järvinen, L, Wray, NR & Freimer, NB 2012, 'A Genome-Wide Meta-Analysis of Association Studies of Cloninger’s Temperament Scales.', Translational Psychiatry, vol. 2, no. 5, e116, pp. e116. https://doi.org/10.1038/tp.2012.37

TY - JOUR

T1 - A Genome-Wide Meta-Analysis of Association Studies of Cloninger’s Temperament Scales.

AU - Service, S.K.

AU - Verweij, K.J.H.

AU - Lahti, J.

AU - Congdon, E.

AU - Ekelund, J.

AU - Hintsanen, M.

AU - Räikkönen, K.

AU - Lehtimäki, T.

AU - Kähönen, M.

AU - Widen, E.

AU - Taanila, A.

AU - Veijola, J.

AU - Heath, A.C.

AU - Madden, P.A.F.

AU - Montgomery, G.W.

AU - Sabatti, C.

AU - Järvelin, M.R.

AU - Palotie, A.

AU - Raitakari, O.

AU - Viikari, J.

AU - Martin, N.G.

AU - Eriksson, J.G.

AU - Keltikangas-Järvinen, L.

AU - Wray, N.R.

AU - Freimer, N.B.

PY - 2012

Y1 - 2012

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AB - Temperament has a strongly heritable component, yet multiple independent genome-wide studies have failed to identify significant genetic associations. We have assembled the largest sample to date of persons with genome-wide genotype data, who have been assessed with Cloninger's Temperament and Character Inventory. Sum scores for novelty seeking, harm avoidance, reward dependence and persistence have been measured in over 11 000 persons collected in four different cohorts. Our study had >80% power to identify genome-wide significant loci (P<1.25 × 10

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JO - Translational Psychiatry

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M1 - e116

ER -

A Genome-Wide Meta-Analysis of Association Studies of Cloninger’s Temperament Scales.

Abstract

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