A genome-wide siRNA screen for regulators of tumor suppressor p53 activity in human non-small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment

Ellen Siebring-van Olst; Maxime Blijlevens; Renee X. de Menezes; Ida H. van der Meulen-Muileman; Egbert F. Smit; Victor W. van Beusechem

doi:https://doi.org/10.1002/1878-0261.12052

A genome-wide siRNA screen for regulators of tumor suppressor p53 activity in human non-small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment

Ellen Siebring-van Olst, Maxime Blijlevens, Renee X. de Menezes, Ida H. van der Meulen-Muileman, Egbert F. Smit, Victor W. van Beusechem

Research output: Contribution to journal › Article › Academic › peer-review

46 Citations (Scopus)

Original language	English
Pages (from-to)	534-551
Journal	Molecular Oncology
Volume	11
Issue number	5
DOIs	https://doi.org/10.1002/1878-0261.12052
Publication status	Published - May 2017

Keywords

NSCLC
RNA splice factor
RNAi screen
p53 pathway inhibitor
spliceosome

Access to Document

https://doi.org/10.1002/1878-0261.12052

Cite this

Siebring-van Olst, E., Blijlevens, M., de Menezes, R. X., van der Meulen-Muileman, I. H., Smit, E. F., & van Beusechem, V. W. (2017). A genome-wide siRNA screen for regulators of tumor suppressor p53 activity in human non-small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment. Molecular Oncology, 11(5), 534-551. https://doi.org/10.1002/1878-0261.12052

@article{7357761fc3ed4c09898c40a9a1780b4f,

title = "A genome-wide siRNA screen for regulators of tumor suppressor p53 activity in human non-small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment",

keywords = "NSCLC, RNA splice factor, RNAi screen, p53 pathway inhibitor, spliceosome",

author = "{Siebring-van Olst}, Ellen and Maxime Blijlevens and {de Menezes}, {Renee X.} and {van der Meulen-Muileman}, {Ida H.} and Smit, {Egbert F.} and {van Beusechem}, {Victor W.}",

year = "2017",

month = may,

doi = "https://doi.org/10.1002/1878-0261.12052",

language = "English",

volume = "11",

pages = "534--551",

journal = "Molecular Oncology",

issn = "1878-0261",

publisher = "Elsevier",

number = "5",

}

Siebring-van Olst, E, Blijlevens, M, de Menezes, RX, van der Meulen-Muileman, IH, Smit, EF & van Beusechem, VW 2017, 'A genome-wide siRNA screen for regulators of tumor suppressor p53 activity in human non-small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment', Molecular Oncology, vol. 11, no. 5, pp. 534-551. https://doi.org/10.1002/1878-0261.12052

A genome-wide siRNA screen for regulators of tumor suppressor p53 activity in human non-small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment. / Siebring-van Olst, Ellen; Blijlevens, Maxime; de Menezes, Renee X. et al.
In: Molecular Oncology, Vol. 11, No. 5, 05.2017, p. 534-551.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - A genome-wide siRNA screen for regulators of tumor suppressor p53 activity in human non-small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment

AU - Siebring-van Olst, Ellen

AU - Blijlevens, Maxime

AU - de Menezes, Renee X.

AU - van der Meulen-Muileman, Ida H.

AU - Smit, Egbert F.

AU - van Beusechem, Victor W.

PY - 2017/5

Y1 - 2017/5

KW - NSCLC

KW - RNA splice factor

KW - RNAi screen

KW - p53 pathway inhibitor

KW - spliceosome

U2 - https://doi.org/10.1002/1878-0261.12052

DO - https://doi.org/10.1002/1878-0261.12052

M3 - Article

C2 - 28296343

SN - 1878-0261

VL - 11

SP - 534

EP - 551

JO - Molecular Oncology

JF - Molecular Oncology

IS - 5

ER -

Siebring-van Olst E, Blijlevens M, de Menezes RX, van der Meulen-Muileman IH, Smit EF, van Beusechem VW. A genome-wide siRNA screen for regulators of tumor suppressor p53 activity in human non-small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment. Molecular Oncology. 2017 May;11(5):534-551. doi: https://doi.org/10.1002/1878-0261.12052