A guide to appropriately planning and conducting meta-analyses—Part 1: indications, assumptions and understanding risk of bias

Jeffrey Kay, Kyle N. Kunze, Ayoosh Pareek, Jari Dahmen, Darren de Sa, Jon Karlsson

Research output: Contribution to journalReview articleAcademicpeer-review

1 Citation (Scopus)

Abstract

A meta-analysis is the quantitative synthesis of data from two or more individual studies and are as a rule an important method of obtaining a more accurate estimate of the direction and magnitude of a treatment effect. However, it is imperative that the meta-analysis be performed with proper, rigorous methodology to ensure validity of the results and their interpretation. In this article the authors will review the most important questions researchers should consider when planning a meta-analysis to ensure proper indications and methodologies, minimize the risk of bias, and avoid misleading conclusions.
Original languageEnglish
JournalKnee surgery, sports traumatology, arthroscopy
Early online date2022
DOIs
Publication statusE-pub ahead of print - 2022

Keywords

  • Bias
  • Indications
  • Meta-analysis
  • Methodology

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