TY - JOUR
T1 - A high-fat diet increases influenza a virus-associated cardiovascular damage
AU - Siegers, Jurre Y.
AU - Novakovic, Boris
AU - Hulme, Katina D.
AU - Marshall, Rebecca J.
AU - Bloxham, Conor J.
AU - Thomas, Walter G.
AU - Reichelt, Mellissa E.
AU - Leijten, Lonneke
AU - van Run, Peter
AU - Knox, Karen
AU - Sokolowski, Kamil A.
AU - Tse, Brian W.C.
AU - Chew, Keng Yih
AU - Christ, Angelika N.
AU - Howe, Greg
AU - Bruxner, Timothy J.C.
AU - Karolyi, Mario
AU - Pawelka, Erich
AU - Koch, Rebecca M.
AU - Bellmann-Weiler, Rosa
AU - Burkert, Francesco
AU - Weiss, Günter
AU - Samanta, Romit J.
AU - Openshaw, Peter J.M.
AU - Bielefeldt-Ohmann, Helle
AU - van Riel, Debby
AU - Short, Kirsty R.
N1 - Funding Information: This work was supported by the Erasmus Trust Fund Foundation (grant to J. Y. S.); the Netherlands Organization for Scientific Research (grant numbers 91614115 and 91718308 to D. v. R.); the Erasmus Medical Center Foundation (grant to D. v. R.); and the Australian Research Council (grant number DE180100512 to K. R. S.). The Preclinical Imaging Facility, Translational Research Institute is supported by the Australian Research Council (grant number LE150100067) and the Australian Federal Government. Publisher Copyright: © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Background. Influenza A virus (IAV) causes a wide range of extrarespiratory complications. However, the role of host factors in these complications of influenza virus infection remains to be defined. Methods. Here, we sought to use transcriptional profiling, virology, histology, and echocardiograms to investigate the role of a high-fat diet in IAV-associated cardiac damage. Results. Transcriptional profiling showed that, compared to their low-fat counterparts (LF mice), mice fed a high-fat diet (HF mice) had impairments in inflammatory signaling in the lung and heart after IAV infection. This was associated with increased viral titers in the heart, increased left ventricular mass, and thickening of the left ventricular wall in IAV-infected HF mice compared to both IAV-infected LF mice and uninfected HF mice. Retrospective analysis of clinical data revealed that cardiac complications were more common in patients with excess weight, an association which was significant in 2 out of 4 studies. Conclusions. Together, these data provide the first evidence that a high-fat diet may be a risk factor for the development of IAV-associated cardiovascular damage and emphasizes the need for further clinical research in this area.
AB - Background. Influenza A virus (IAV) causes a wide range of extrarespiratory complications. However, the role of host factors in these complications of influenza virus infection remains to be defined. Methods. Here, we sought to use transcriptional profiling, virology, histology, and echocardiograms to investigate the role of a high-fat diet in IAV-associated cardiac damage. Results. Transcriptional profiling showed that, compared to their low-fat counterparts (LF mice), mice fed a high-fat diet (HF mice) had impairments in inflammatory signaling in the lung and heart after IAV infection. This was associated with increased viral titers in the heart, increased left ventricular mass, and thickening of the left ventricular wall in IAV-infected HF mice compared to both IAV-infected LF mice and uninfected HF mice. Retrospective analysis of clinical data revealed that cardiac complications were more common in patients with excess weight, an association which was significant in 2 out of 4 studies. Conclusions. Together, these data provide the first evidence that a high-fat diet may be a risk factor for the development of IAV-associated cardiovascular damage and emphasizes the need for further clinical research in this area.
KW - Body mass index
KW - Cardiac disease
KW - Extrarespiratory complications
KW - High-fat diet
KW - Influenza
KW - Obesity
KW - Overweight
UR - http://www.scopus.com/inward/record.url?scp=85086050089&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/infdis/jiaa159
DO - https://doi.org/10.1093/infdis/jiaa159
M3 - Article
C2 - 32246148
SN - 0022-1899
VL - 222
SP - 820
EP - 831
JO - Journal of infectious diseases
JF - Journal of infectious diseases
IS - 5
ER -