Abstract
PurposeTo compute cohort-averaged wall shear stress (WSS) maps in the thoracic aorta of patients with aortic dilatation or valvular stenosis and to detect abnormal regional WSS. MethodsSystolic WSS vectors, estimated from four-dimensional flow MRI data, were calculated along the thoracic aorta lumen in 10 controls, 10 patients with dilated aortas, and 10 patients with aortic valve stenosis. Three-dimensional segmentations of each aorta were coregistered by group and used to create a cohort-specific aortic geometry. The WSS vectors of each subject were interpolated onto the corresponding cohort-specific geometry to create cohort-averaged WSS maps. A Wilcoxon rank sum test was used to generate aortic P-value maps (P <0.05) representing regional relative WSS differences between groups. ResultsCohort-averaged systolic WSS maps and P-value maps were successfully created for all cohorts and comparisons. The dilation cohort showed significantly lower WSS on 7% of the ascending aorta surface, whereas the stenosis cohort showed significantly higher WSS on 34% of the ascending aorta surface. ConclusionsThe findings of this study demonstrated the feasibility of generating cohort-averaged WSS maps for the visualization and identification of regionally altered WSS in the presence of disease, compared with healthy controls. Magn Reson Med 73:1216-1227, 2015. (c) 2014 Wiley Periodicals, Inc
Original language | English |
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Pages (from-to) | 1216-1227 |
Number of pages | 12 |
Journal | Magnetic resonance in medicine |
Volume | 73 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2015 |
Keywords
- Aged
- Algorithms
- Aorta, Thoracic/physiopathology
- Aortic Valve Stenosis/diagnosis
- Female
- Humans
- Image Interpretation, Computer-Assisted/methods
- Imaging, Three-Dimensional/methods
- Magnetic Resonance Angiography/methods
- Middle Aged
- Reproducibility of Results
- Sensitivity and Specificity
- Shear Strength
- Stress, Mechanical