TY - JOUR
T1 - A new murine model to study the pathogenesis of tuberculous meningitis
AU - Van Well, Gijs Th J
AU - Wieland, Catharina W.
AU - Florquin, Sandrine
AU - Roord, John J.
AU - Van Der Poll, Tom
AU - Van Furth, A. Marceline
PY - 2007/3/1
Y1 - 2007/3/1
N2 - Tuberculous meningitis (TM) is a severe complication of tuberculosis that mainly occurs during childhood. No murine models are available to study this disease. The purpose of the present study was to develop a murine model to investigate the pathogenesis of TM. Mice were intracerebrally injected with Mycobacterium tuberculosis. Bacilli could be cultured from brain homogenates, and, on histopathological examination, all mice were found to have meningeal cellular infiltration. We found elevated levels of chemoattractants for mononuclear phagocytes and neutrophilic granulocytes. This is the first murine model for TM that can be used for research on the host response to TM, in particular the innate immune response.
AB - Tuberculous meningitis (TM) is a severe complication of tuberculosis that mainly occurs during childhood. No murine models are available to study this disease. The purpose of the present study was to develop a murine model to investigate the pathogenesis of TM. Mice were intracerebrally injected with Mycobacterium tuberculosis. Bacilli could be cultured from brain homogenates, and, on histopathological examination, all mice were found to have meningeal cellular infiltration. We found elevated levels of chemoattractants for mononuclear phagocytes and neutrophilic granulocytes. This is the first murine model for TM that can be used for research on the host response to TM, in particular the innate immune response.
UR - http://www.scopus.com/inward/record.url?scp=33847067894&partnerID=8YFLogxK
U2 - https://doi.org/10.1086/511273
DO - https://doi.org/10.1086/511273
M3 - Article
C2 - 17262711
SN - 0022-1899
VL - 195
SP - 694
EP - 697
JO - Journal of infectious diseases
JF - Journal of infectious diseases
IS - 5
ER -