A new murine model to study the pathogenesis of tuberculous meningitis

Gijs Th J Van Well, Catharina W. Wieland, Sandrine Florquin, John J. Roord, Tom Van Der Poll, A. Marceline Van Furth

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Tuberculous meningitis (TM) is a severe complication of tuberculosis that mainly occurs during childhood. No murine models are available to study this disease. The purpose of the present study was to develop a murine model to investigate the pathogenesis of TM. Mice were intracerebrally injected with Mycobacterium tuberculosis. Bacilli could be cultured from brain homogenates, and, on histopathological examination, all mice were found to have meningeal cellular infiltration. We found elevated levels of chemoattractants for mononuclear phagocytes and neutrophilic granulocytes. This is the first murine model for TM that can be used for research on the host response to TM, in particular the innate immune response.

Original languageEnglish
Pages (from-to)694-697
Number of pages4
JournalJournal of infectious diseases
Issue number5
Publication statusPublished - 1 Mar 2007

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