TY - JOUR
T1 - A Novel Astrovirus-Like RNA Virus Detected in Human Stool
AU - Oude Munnink, Bas B.
AU - Cotten, Matthew
AU - Canuti, Marta
AU - Deijs, Martin
AU - Jebbink, Maarten F.
AU - van Hemert, Formijn J.
AU - Phan, My V. T.
AU - Bakker, Margreet
AU - Jazaeri Farsani, Seyed Mohammad
AU - Kellam, Paul
AU - van der Hoek, Lia
PY - 2016
Y1 - 2016
N2 - Several novel clades of astroviruses have recently been identified in human faecal samples. Here, we describe a novel astrovirus-like RNA virus detected in human stools, which we have tentatively named bastrovirus. The genome of this novel virus consists of 6,300 nucleotides organized in three open reading frames. Several sequence divergent strains were detected sharing 67-93 per cent nucleotide identity. Bastrovirus encodes a putative structural protein that is homologous to the capsid protein found in members of the Astroviridae family (45% amino acid identity). The virus also encodes a putative non-structural protein that is genetically distant from astroviruses but shares some homology to the non-structural protein encoded by members of the Hepeviridae family (28% amino acid identity). This novel bastrovirus is present in 8.7 per cent (35/400) of faecal samples collected from 300 HIV-1-positive and 100 HIV-1-negative individuals suggesting common occurrence of the virus. However, whether the source of the virus is infected human cells or other, for example, dietary, remains to be determined
AB - Several novel clades of astroviruses have recently been identified in human faecal samples. Here, we describe a novel astrovirus-like RNA virus detected in human stools, which we have tentatively named bastrovirus. The genome of this novel virus consists of 6,300 nucleotides organized in three open reading frames. Several sequence divergent strains were detected sharing 67-93 per cent nucleotide identity. Bastrovirus encodes a putative structural protein that is homologous to the capsid protein found in members of the Astroviridae family (45% amino acid identity). The virus also encodes a putative non-structural protein that is genetically distant from astroviruses but shares some homology to the non-structural protein encoded by members of the Hepeviridae family (28% amino acid identity). This novel bastrovirus is present in 8.7 per cent (35/400) of faecal samples collected from 300 HIV-1-positive and 100 HIV-1-negative individuals suggesting common occurrence of the virus. However, whether the source of the virus is infected human cells or other, for example, dietary, remains to be determined
U2 - https://doi.org/10.1093/ve/vew005
DO - https://doi.org/10.1093/ve/vew005
M3 - Article
C2 - 27774298
SN - 2057-1577
VL - 2
SP - vew005
JO - Virus evolution
JF - Virus evolution
IS - 1
ER -