TY - GEN
T1 - A novel computational model of the human sinoatrial action potential
AU - Fabbri, Alan
AU - Fantini, Matteo
AU - Wilders, Ronald
AU - Severi, Stefano
N1 - Publisher Copyright: © 2015 CCAL. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2015/2/16
Y1 - 2015/2/16
N2 - The sinoatrial node (SAN) tissue is responsible for the heart rhythm in physiological conditions. SAN cells are self-oscillating and the phenomena underlying this feature are well-described through electrophysiological experiments carried out on animals. Recently, human SAN cell data were recorded, but a human SAN action potential (AP) mathematical model is still lacking. Aim of this work is the formulation of a human SAN AP model that is able to reproduce the available experimental data. We started from the Severi-DiFrancesco SAN model (rabbit) and modified ion currents and calcium handling on the basis of available experimental data. The AP waveform and calcium transient generated by the model were compared to experimental traces. We also studied the effect of If ('funny current') block on cycle length. The model generates action potentials and calcium transients in line with experimental data. It can provide new insights into the phenomena that lead to the generation of SAN AP and allows us to study the effects of drugs that modulate the pacemaker activity.
AB - The sinoatrial node (SAN) tissue is responsible for the heart rhythm in physiological conditions. SAN cells are self-oscillating and the phenomena underlying this feature are well-described through electrophysiological experiments carried out on animals. Recently, human SAN cell data were recorded, but a human SAN action potential (AP) mathematical model is still lacking. Aim of this work is the formulation of a human SAN AP model that is able to reproduce the available experimental data. We started from the Severi-DiFrancesco SAN model (rabbit) and modified ion currents and calcium handling on the basis of available experimental data. The AP waveform and calcium transient generated by the model were compared to experimental traces. We also studied the effect of If ('funny current') block on cycle length. The model generates action potentials and calcium transients in line with experimental data. It can provide new insights into the phenomena that lead to the generation of SAN AP and allows us to study the effects of drugs that modulate the pacemaker activity.
UR - http://www.scopus.com/inward/record.url?scp=84964026633&partnerID=8YFLogxK
U2 - https://doi.org/10.1109/CIC.2015.7411051
DO - https://doi.org/10.1109/CIC.2015.7411051
M3 - Conference contribution
T3 - Computing in Cardiology
SP - 877
EP - 880
BT - Computing in Cardiology Conference 2015, CinC 2015
A2 - Murray, Alan
PB - IEEE Computer Society
T2 - 42nd Computing in Cardiology Conference, CinC 2015
Y2 - 6 September 2015 through 9 September 2015
ER -