TY - JOUR
T1 - A novel host-parasite lipid cross-talk - Schistosomal lyso-phosphatidylserine activates Toll-like receptor 2 and affects immune polarization
AU - van der Kleij, Desiree
AU - Latz, Eicke
AU - Brouwers, Jos F. H. M.
AU - Kruize, Yvonne C. M.
AU - Schmitz, Marion
AU - Kurt-Jones, Evelyn A.
AU - Espevik, Terje
AU - de Jong, Esther C.
AU - Kapsenberg, Martien L.
AU - Golenbock, Douglas T.
AU - Tielens, Aloysius G. M.
AU - Yazdanbakhsh, Maria
PY - 2002
Y1 - 2002
N2 - Schistosome infections are characterized by prominent T cell hyporesponsiveness during the chronic stage of infection. We found that schistosome-specific phosphatidylserine (PS) activated TLR2 and affected dendritic cells such that mature dendritic cells gained the ability to induce the development of IL-10-producing regulatory T cells. Using mass spectrometry, schistosomal lysophosphatidylserine (lyso-PS) was identified as the TLR2-activating molecule. This activity appears to be a unique property of schistosomal lyso-PS, containing specific acyl chains, because neither a synthetic lyso-PS (16:0) nor PS isolated from the mammalian host activates TLR2. Taken together, these findings provide evidence for a novel host-parasite interaction that may be central to long term survival of the parasite and limited host pathology with implications beyond parasitology
AB - Schistosome infections are characterized by prominent T cell hyporesponsiveness during the chronic stage of infection. We found that schistosome-specific phosphatidylserine (PS) activated TLR2 and affected dendritic cells such that mature dendritic cells gained the ability to induce the development of IL-10-producing regulatory T cells. Using mass spectrometry, schistosomal lysophosphatidylserine (lyso-PS) was identified as the TLR2-activating molecule. This activity appears to be a unique property of schistosomal lyso-PS, containing specific acyl chains, because neither a synthetic lyso-PS (16:0) nor PS isolated from the mammalian host activates TLR2. Taken together, these findings provide evidence for a novel host-parasite interaction that may be central to long term survival of the parasite and limited host pathology with implications beyond parasitology
U2 - https://doi.org/10.1074/jbc.M206941200
DO - https://doi.org/10.1074/jbc.M206941200
M3 - Article
C2 - 12359728
SN - 0021-9258
VL - 277
SP - 48122
EP - 48129
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 50
ER -