A power analysis for future clinical trials on the potential adverse effects of SSRIs on amygdala reactivity

M. A. Bottelier; A. Schrantee; G. van Wingen; H. G. Ruhé; M. B. de Ruiter; L. Reneman

doi:https://doi.org/10.1007/s11515-016-1402-6

A power analysis for future clinical trials on the potential adverse effects of SSRIs on amygdala reactivity

M. A. Bottelier, A. Schrantee, G. van Wingen, H. G. Ruhé, M. B. de Ruiter, L. Reneman

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

Treatment of adolescents with antidepressants may induce an increased risk for suicidality in this population. The activity of the amygdala during processing of emotional faces with functional Magnetic Resonance Imaging (fMRI) is a well-known measure of emotional dysregulation. Based upon data of our prematurely ended randomized clinical trial with fluoxetine (NTR3103) in anxious and or depressed girls (12–14 years of age) we calculated that with the found effect size of r = 0.66, compared to placebo, only 8 subjects are needed to demonstrate increased amygdala activity following 16 weeks of treatment with fluoxetine.

Original language	English
Pages (from-to)	256-259
Number of pages	4
Journal	Frontiers in Biology
Volume	11
Issue number	3
DOIs	https://doi.org/10.1007/s11515-016-1402-6
Publication status	Published - 1 Jun 2016

Keywords

SSRI
adverse effects
amygdala reactivity
anxiety
depression

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https://doi.org/10.1007/s11515-016-1402-6

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AU - de Ruiter, M. B.

AU - Reneman, L.

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A power analysis for future clinical trials on the potential adverse effects of SSRIs on amygdala reactivity

Abstract

Keywords

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