TY - JOUR
T1 - A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium
AU - Alzheimer's Disease Neuroimaging Initiative
AU - Oppedal, Ketil
AU - Ferreira, Daniel
AU - Cavallin, Lena
AU - Lemstra, Afina W.
AU - ten Kate, Mara
AU - Padovani, Alessandro
AU - Rektorova, Irena
AU - Bonanni, Laura
AU - Wahlund, Lars-Olof
AU - Engedal, Knut
AU - Nobili, Flavio
AU - Kramberger, Milica
AU - Taylor, John-Paul
AU - Hort, Jakub
AU - Snædal, Jon
AU - Blanc, Frederic
AU - Walker, Zuzana
AU - Antonini, Angelo
AU - Westman, Eric
AU - Aarsland, Dag
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Introduction: We explored regional brain atrophy patterns and their clinical correlates in dementia with Lewy bodies (DLB). Methods: In this multicentre study, we included a total of 333 patients with DLB, 352 patients with Alzheimer's disease (AD), and 233 normal controls and used medial temporal lobe atrophy, posterior atrophy, and frontal atrophy (GCA-F) visual rating scales. Patients were classified according to four atrophy patterns. Results: Patients with DLB had higher scores on all the three atrophy scales than normal controls but had less medial temporal lobe atrophy than those with AD (all P values <.001). A signature hippocampal-sparing pattern of regional atrophy was observed in DLB. The magnetic resonance imaging measures showed 65% ability to discriminate between DLB and AD and marginally contributed to the discrimination over and above the core clinical features. Discussion: The most common pattern of atrophy of DLB was hippocampal-sparing. Future studies should explore whether comorbid AD pathology underlies the atrophy patterns seen in DLB.
AB - Introduction: We explored regional brain atrophy patterns and their clinical correlates in dementia with Lewy bodies (DLB). Methods: In this multicentre study, we included a total of 333 patients with DLB, 352 patients with Alzheimer's disease (AD), and 233 normal controls and used medial temporal lobe atrophy, posterior atrophy, and frontal atrophy (GCA-F) visual rating scales. Patients were classified according to four atrophy patterns. Results: Patients with DLB had higher scores on all the three atrophy scales than normal controls but had less medial temporal lobe atrophy than those with AD (all P values <.001). A signature hippocampal-sparing pattern of regional atrophy was observed in DLB. The magnetic resonance imaging measures showed 65% ability to discriminate between DLB and AD and marginally contributed to the discrimination over and above the core clinical features. Discussion: The most common pattern of atrophy of DLB was hippocampal-sparing. Future studies should explore whether comorbid AD pathology underlies the atrophy patterns seen in DLB.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85057618363&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30439333
U2 - https://doi.org/10.1016/j.jalz.2018.09.011
DO - https://doi.org/10.1016/j.jalz.2018.09.011
M3 - Article
C2 - 30439333
SN - 1552-5260
VL - 15
SP - 400
EP - 409
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 3
ER -