A star with stripes: zebrafish as an infection model

Astrid M. van der Sar, Ben J. Appelmelk, Christina M. J. E. Vandenbroucke-Grauls, Wilbert Bitter

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The zebrafish, one of the favourite animals of developmental biologists, is rapidly gaining ground in infection models. Various experimental infection models have been set up to study both human and fish pathogens in more detail. The most interesting of these pathogens is perhaps Mycobacterium marinum. a close relative of Mycobacterium tuberculosis, and causes fish tuberculosis. With the zebrafish, genetic screens in a vertebrate host with a fully developed immune system are possible. In addition, bacterial infections can be analysed in real-time in zebrafish embryos. Here, we discuss the use of the zebrafish as a host for studying infectious diseases, and also the challenges, benefits and hurdles associated with using this model
Original languageEnglish
Pages (from-to)451-457
JournalTrends in Microbiology
Issue number10
Early online date1 Oct 2004
Publication statusPublished - 2004

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