TY - JOUR
T1 - A star with stripes: zebrafish as an infection model
AU - van der Sar, Astrid M.
AU - Appelmelk, Ben J.
AU - Vandenbroucke-Grauls, Christina M. J. E.
AU - Bitter, Wilbert
PY - 2004
Y1 - 2004
N2 - The zebrafish, one of the favourite animals of developmental biologists, is rapidly gaining ground in infection models. Various experimental infection models have been set up to study both human and fish pathogens in more detail. The most interesting of these pathogens is perhaps Mycobacterium marinum. a close relative of Mycobacterium tuberculosis, and causes fish tuberculosis. With the zebrafish, genetic screens in a vertebrate host with a fully developed immune system are possible. In addition, bacterial infections can be analysed in real-time in zebrafish embryos. Here, we discuss the use of the zebrafish as a host for studying infectious diseases, and also the challenges, benefits and hurdles associated with using this model
AB - The zebrafish, one of the favourite animals of developmental biologists, is rapidly gaining ground in infection models. Various experimental infection models have been set up to study both human and fish pathogens in more detail. The most interesting of these pathogens is perhaps Mycobacterium marinum. a close relative of Mycobacterium tuberculosis, and causes fish tuberculosis. With the zebrafish, genetic screens in a vertebrate host with a fully developed immune system are possible. In addition, bacterial infections can be analysed in real-time in zebrafish embryos. Here, we discuss the use of the zebrafish as a host for studying infectious diseases, and also the challenges, benefits and hurdles associated with using this model
U2 - https://doi.org/10.1016/j.tim.2004.08.001
DO - https://doi.org/10.1016/j.tim.2004.08.001
M3 - Review article
C2 - 15381194
SN - 0966-842X
VL - 12
SP - 451
EP - 457
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 10
ER -
