TY - JOUR
T1 - A symbiotic concept of autoimmunity and tumour immunity: lessons from vitiligo
AU - Das, P. K.
AU - van den Wijngaard, R. M.
AU - Wankowicz-Kalinska, A.
AU - Le Poole, I. C.
PY - 2001
Y1 - 2001
N2 - Vitiligo is a skin disease in which melanocytes (MCs) are eradicated from lesional epidermis, resulting in disfiguring loss of pigment. MCs are destroyed by MC-reactive T cells, as well as other non-immune and immune components. Similarities exist between the autoimmunity observed in vitiligo and the tumour immunity observed in melanoma immuno-surveillance. An analysis of these mechanisms might lead to the development of new therapies for both vitiligo and melanoma
AB - Vitiligo is a skin disease in which melanocytes (MCs) are eradicated from lesional epidermis, resulting in disfiguring loss of pigment. MCs are destroyed by MC-reactive T cells, as well as other non-immune and immune components. Similarities exist between the autoimmunity observed in vitiligo and the tumour immunity observed in melanoma immuno-surveillance. An analysis of these mechanisms might lead to the development of new therapies for both vitiligo and melanoma
U2 - https://doi.org/10.1016/S1471-4906(00)01844-5
DO - https://doi.org/10.1016/S1471-4906(00)01844-5
M3 - Article
C2 - 11286727
SN - 1471-4906
VL - 22
SP - 130
EP - 136
JO - Trends in immunology
JF - Trends in immunology
IS - 3
ER -