TY - JOUR
T1 - A4 protein in alzheimer’s disease
T2 - Primary and secondary cellular events in extracellular amyloid deposition
AU - Rozemuller, J. M.
AU - Stam, F. C.
AU - Eikelenboom, P.
AU - Beyreuther, K.
AU - Masters, C. L.
PY - 1989/1/1
Y1 - 1989/1/1
N2 - This study was designed to investigate the role of serum proteins, microglia, glial fibrillary acidic protein (GFAP) positive cells and dystrophic neurites in the genesis of cerebral amyloid. Using A4 protein antisera, we found an amorphous non-congophilic, form of plaque, which was not seen in Bielschowsky silver staining or Bodian impregnations. GFAP-positive glial cells, cells immunolabelled for some macrophage markers and dystrophic neurites were detected in congophilic plaques with crystalline amyloid, but not in the amorphous, non-congophilic plaques. The presence of α1-antichymotrypsin, complement factors and P component, but not of common serum proteins in both the amorphous and congophilic plaques, indicates that these three proteins may have a pathogenetic role in amyloid formation. Amorphous plaques may be the earlier forms of plaque and consequently, the presence of reactive cells and dystrophic neurites may be secondary phenomena.
AB - This study was designed to investigate the role of serum proteins, microglia, glial fibrillary acidic protein (GFAP) positive cells and dystrophic neurites in the genesis of cerebral amyloid. Using A4 protein antisera, we found an amorphous non-congophilic, form of plaque, which was not seen in Bielschowsky silver staining or Bodian impregnations. GFAP-positive glial cells, cells immunolabelled for some macrophage markers and dystrophic neurites were detected in congophilic plaques with crystalline amyloid, but not in the amorphous, non-congophilic plaques. The presence of α1-antichymotrypsin, complement factors and P component, but not of common serum proteins in both the amorphous and congophilic plaques, indicates that these three proteins may have a pathogenetic role in amyloid formation. Amorphous plaques may be the earlier forms of plaque and consequently, the presence of reactive cells and dystrophic neurites may be secondary phenomena.
KW - A4 protein
KW - Alzheimer’s disease
KW - Amyloid, cerebral
KW - Macrophages
KW - Serine protease inhibitor
KW - Serum proteins
UR - http://www.scopus.com/inward/record.url?scp=0024428072&partnerID=8YFLogxK
U2 - https://doi.org/10.1097/00005072-198911000-00009
DO - https://doi.org/10.1097/00005072-198911000-00009
M3 - Article
C2 - 2677252
SN - 0022-3069
VL - 48
SP - 674
EP - 691
JO - Journal of Neuropathology and Experimental Neurology
JF - Journal of Neuropathology and Experimental Neurology
IS - 6
ER -