TY - JOUR
T1 - Accelerated vertebral bone loss in relation to the menopause: a cross-sectional study on lumbar bone density in 286 women of 46 to 55 years of age
AU - Elders, Petra J. M.
AU - Netelenbos, J. Coen
AU - Lips, Paul
AU - van Ginkel, Floris C.
AU - van der Stelt, Paul F.
PY - 1988
Y1 - 1988
N2 - Bone mineral density (BMD) of the lumbar spine was measured in 286 women (46-55 years of age) using dual photon absorptiometry. The women were classified in three categories: premenopausal, perimenopausal and postmenopausal. The postmenopausal group was subdivided according to the number of years since the last uterine bleeding. with multiple linear regression analysis of lumbar BMD on age and menopausal status, an acceleration of bone loss was observed during the perimenopausal period and the following first two postmenopausal years. No significant bone loss was detected in relation to age or during the later postmenopausal years. Applying both an additive and a multiplicative model of bone loss, the mean perimenopausal bone loss was 0.061 gramequivalents hydroxyapatite (geqHA)/cm2 and 6.4%, respectively. In the first 2 postmenopausal years the mean bone loss was 0.044 geqHA/cm2 and 5.1% per year. These results suggest a substantial menopause related acceleration of lumbar bone loss in a relatively short time span with its onset in the perimenopausal period. © 1988.
AB - Bone mineral density (BMD) of the lumbar spine was measured in 286 women (46-55 years of age) using dual photon absorptiometry. The women were classified in three categories: premenopausal, perimenopausal and postmenopausal. The postmenopausal group was subdivided according to the number of years since the last uterine bleeding. with multiple linear regression analysis of lumbar BMD on age and menopausal status, an acceleration of bone loss was observed during the perimenopausal period and the following first two postmenopausal years. No significant bone loss was detected in relation to age or during the later postmenopausal years. Applying both an additive and a multiplicative model of bone loss, the mean perimenopausal bone loss was 0.061 gramequivalents hydroxyapatite (geqHA)/cm2 and 6.4%, respectively. In the first 2 postmenopausal years the mean bone loss was 0.044 geqHA/cm2 and 5.1% per year. These results suggest a substantial menopause related acceleration of lumbar bone loss in a relatively short time span with its onset in the perimenopausal period. © 1988.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0023815439&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/3265068
U2 - https://doi.org/10.1016/0169-6009(88)90003-7
DO - https://doi.org/10.1016/0169-6009(88)90003-7
M3 - Article
C2 - 3265068
SN - 0169-6009
VL - 5
SP - 11
EP - 19
JO - Bone and mineral
JF - Bone and mineral
IS - 1
ER -