TY - JOUR
T1 - Acceleration of blood flow velocity in the carotid artery and myocardial contractility in the newborn lamb
AU - van Bel, Frank
AU - Sch1pper, Inger B.
AU - Klautz, Robert J. M.
AU - Teitel, David F.
AU - Steendijk, Paul
AU - Baan, Jan
PY - 1991
Y1 - 1991
N2 - We investigated the influence of quantitative changes in myocardial contractile state, reflected by changes in the end-systolic pressure-volume relationship (its slope and volume intercept) and by changes in the slope of the relationship between change in pressure per unit time and end-diastolic volume induced by β-adrenergic stimulation or inhibition, on the Doppler derived blood flow velocity wave form of the carotid artery, using a newborn lamb model. Acceleration time of the velocity wave form was investigated during control state I, during 4 and 8 µg/kg/min dobutamine infusion, during control state II, and during 0.5 mg/kg propranolol infusion, respectively. Using multiple linear regression analysis with dummy variables, confounding effects such as interanimal variability were removed. Acceleration time showed a strong relationship to both the slope and the volume intercept of the end-systolic pressure-volume relationship and to the change in pressure per unit time-end-diastolic volume relationship. The relations appeared to be independent of aortic pressure and relative resistance in the vascular bed of the carotid artery. These results indicate that acceleration of cerebral blood velocity may prove to be useful in assessing changes in myocardial contractile state of the newborn. © 1991 International Pediatric Research Foundation, Inc.
AB - We investigated the influence of quantitative changes in myocardial contractile state, reflected by changes in the end-systolic pressure-volume relationship (its slope and volume intercept) and by changes in the slope of the relationship between change in pressure per unit time and end-diastolic volume induced by β-adrenergic stimulation or inhibition, on the Doppler derived blood flow velocity wave form of the carotid artery, using a newborn lamb model. Acceleration time of the velocity wave form was investigated during control state I, during 4 and 8 µg/kg/min dobutamine infusion, during control state II, and during 0.5 mg/kg propranolol infusion, respectively. Using multiple linear regression analysis with dummy variables, confounding effects such as interanimal variability were removed. Acceleration time showed a strong relationship to both the slope and the volume intercept of the end-systolic pressure-volume relationship and to the change in pressure per unit time-end-diastolic volume relationship. The relations appeared to be independent of aortic pressure and relative resistance in the vascular bed of the carotid artery. These results indicate that acceleration of cerebral blood velocity may prove to be useful in assessing changes in myocardial contractile state of the newborn. © 1991 International Pediatric Research Foundation, Inc.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0025989110&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/1956721
U2 - https://doi.org/10.1203/00006450-199110000-00015
DO - https://doi.org/10.1203/00006450-199110000-00015
M3 - Article
C2 - 1956721
SN - 0031-3998
VL - 30
SP - 375
EP - 380
JO - Pediatric Research
JF - Pediatric Research
IS - 4
ER -