Accuracy and the influence of marrow fat on quantitative CT and dual-energy X-ray absorptiometry measurements of the femoral neck in vitro

J W Kuiper, C van Kuijk, J L Grashuis, A G Ederveen, H E Schütte

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Bone mineral measurements with quantitative computed tomography (QCT) and dual-energy X-ray absorptiometry (DXA) were compared with chemical analysis (ChA) to determine (1) the accuracy and (2) the influence of bone marrow fat. Total bone mass of 19 human femoral necks in vitro was determined with QCT and DXA before and after defatting. ChA consisted of defatting and decalcification of the femoral neck samples for determination of bone mineral mass (BmM) and amount of fat. The mean BmM was 4.49 g. Mean fat percentage was 37.2% (23.3%-48.5%). QCT, DXA and ChA before and after defatting were all highly correlated (r > 0.96, p < 0.0001). Before defatting the QCT values were on average 0.35 g less than BmM and the DXA values were on average 0.65 g less than BmM. After defatting, all bone mass values increased; QCT values were on average 0.30 g more than BmM and DXA values were 0.29 g less than BmM. It is concluded that bone mineral measurements of the femoral neck with QCT and DXA are highly correlated with the chemically determined bone mineral mass and that both techniques are influenced by the femoral fat content.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalOsteoporosis international
Issue number1
Publication statusPublished - 1996


  • Absorptiometry, Photon
  • Aged
  • Aged, 80 and over
  • Bone Density
  • Bone Marrow
  • Comparative Study
  • Female
  • Femur Neck
  • Humans
  • Journal Article
  • Lipids
  • Male
  • Reproducibility of Results
  • Tomography, X-Ray Computed

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