TY - JOUR
T1 - Accuracy of approximations to recover incompletely reported logistic regression models depended on other available information
AU - Takada, Toshihiko
AU - van Lieshout, Chris
AU - Schuit, Ewoud
AU - Collins, Gary S.
AU - Moons, Karel G. M.
AU - Reitsma, Johannes B.
AU - Hoogland, Jeroen
N1 - Funding Information: JH and JBR were supported by a TOP grant of the Netherlands Organisation for Health Research and Development (grant: 91215058). Funding Information: Conflict of interests: GSC was supported by the NIHR Biomedical Research Centre, Oxford, and Cancer Research UK (programme grant: C49297/A27294 ). All other authors declared no competing interests. Publisher Copyright: © 2021
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Objective: To provide approximations to recover the full regression equation across different scenarios of incompletely reported prediction models that were developed from binary logistic regression. Study design and setting: In a case study, we considered four common scenarios and illustrated their corresponding approximations: (A) Missing: the intercept, Available: the regression coefficients of predictors, overall frequency of the outcome and descriptive statistics of the predictors; (B) Missing: regression coefficients and the intercept, Available: a simplified score; (C) Missing: regression coefficients and the intercept, Available: a nomogram; (D) Missing: regression coefficients and the intercept, Available: a web calculator. Results: In the scenario A, a simplified approach based on the predicted probability corresponding to the average linear predictor was inaccurate. An approximation based on the overall outcome frequency and an approximation of the linear predictor distribution was more accurate, however, the appropriateness of the underlying assumptions cannot be verified in practice. In the scenario B, the recovered equation was inaccurate due to rounding and categorization of risk scores. In the scenarios C and D, the full regression equation could be recovered with minimal error. Conclusion: The accuracy of the approximations in recovering the regression equation varied depending on the available information.
AB - Objective: To provide approximations to recover the full regression equation across different scenarios of incompletely reported prediction models that were developed from binary logistic regression. Study design and setting: In a case study, we considered four common scenarios and illustrated their corresponding approximations: (A) Missing: the intercept, Available: the regression coefficients of predictors, overall frequency of the outcome and descriptive statistics of the predictors; (B) Missing: regression coefficients and the intercept, Available: a simplified score; (C) Missing: regression coefficients and the intercept, Available: a nomogram; (D) Missing: regression coefficients and the intercept, Available: a web calculator. Results: In the scenario A, a simplified approach based on the predicted probability corresponding to the average linear predictor was inaccurate. An approximation based on the overall outcome frequency and an approximation of the linear predictor distribution was more accurate, however, the appropriateness of the underlying assumptions cannot be verified in practice. In the scenario B, the recovered equation was inaccurate due to rounding and categorization of risk scores. In the scenarios C and D, the full regression equation could be recovered with minimal error. Conclusion: The accuracy of the approximations in recovering the regression equation varied depending on the available information.
KW - Equation
KW - Intercept
KW - Logistic regression
KW - Prediction model
KW - Reporting
KW - Reverse engineering
UR - http://www.scopus.com/inward/record.url?scp=85122042612&partnerID=8YFLogxK
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85122042612&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/34863904
U2 - https://doi.org/10.1016/j.jclinepi.2021.11.033
DO - https://doi.org/10.1016/j.jclinepi.2021.11.033
M3 - Article
C2 - 34863904
SN - 0895-4356
VL - 143
SP - 81
EP - 90
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
ER -