Abstract
Acitretin was introduced as a replacement for etretinate, the ethyl ester of acitretin. Acitretin is eliminated at a much faster rate than etretinate. Although both drugs are teratogens, the replacement was important especially as it allowed for a much shorter post-medication period in which pregnancy should be precluded. Recent findings showed the presence of etretinate in the plasma of acitretin-treated patients. This article gives a review of known metabolic pathways of the retinoids and tries to elucidate the possible conversion of acitretin into etretinate after acitretin ingestion.
Original language | English |
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Pages (from-to) | 33-37 |
Number of pages | 5 |
Journal | Pharmaceutisch Weekblad Scientific Edition |
Volume | 14 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Apr 1992 |
Externally published | Yes |
Keywords
- Acitretin
- Etretinate
- Metabolism
- Pharmacokinetics
- Retinoids
- Teratogens