Activation of vasopressin neurons in the human supraoptic and paraventricular nucleus in senescence and senile dementia

J. E. Hoogendijk; E. Fliers; D. F. Swaab; R. W. Verwer

doi:https://doi.org/10.1016/0022-510X(85)90141-8

Activation of vasopressin neurons in the human supraoptic and paraventricular nucleus in senescence and senile dementia

J. E. Hoogendijk, E. Fliers, D. F. Swaab, R. W. Verwer

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Abstract

A recent study has shown that vasopressin (AVP) cells in the human supraoptic (SON) and paraventricular (PVN) nuclei increase in size after 60 years of age, suggesting that AVP production is increased in senescence. In the present study, the same brain material was used for the determination of nucleolar size in immunocytochemically identified AVP and oxytocin (OXT) neurons as an additional parameter for peptide production. A strong correlation was found between nucleolar size and cell size, both in AVP and OXT neurons. Nucleolar size of AVP but not of OXT neurons increased significantly in senescence. Observations in brains from patients with senile dementia of the Alzheimer type (SDAT) were commensurate with their ages. These results strongly support the hypothesis that AVP neurons in the SON and PVN are activated in old age

Original language	English
Pages (from-to)	291-299
Journal	Journal of the neurological sciences
Volume	69
Issue number	3
DOIs	https://doi.org/10.1016/0022-510X(85)90141-8
Publication status	Published - 1985

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https://doi.org/10.1016/0022-510X(85)90141-8

Cite this

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title = "Activation of vasopressin neurons in the human supraoptic and paraventricular nucleus in senescence and senile dementia",

abstract = "A recent study has shown that vasopressin (AVP) cells in the human supraoptic (SON) and paraventricular (PVN) nuclei increase in size after 60 years of age, suggesting that AVP production is increased in senescence. In the present study, the same brain material was used for the determination of nucleolar size in immunocytochemically identified AVP and oxytocin (OXT) neurons as an additional parameter for peptide production. A strong correlation was found between nucleolar size and cell size, both in AVP and OXT neurons. Nucleolar size of AVP but not of OXT neurons increased significantly in senescence. Observations in brains from patients with senile dementia of the Alzheimer type (SDAT) were commensurate with their ages. These results strongly support the hypothesis that AVP neurons in the SON and PVN are activated in old age",

author = "Hoogendijk, {J. E.} and E. Fliers and Swaab, {D. F.} and Verwer, {R. W.}",

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T1 - Activation of vasopressin neurons in the human supraoptic and paraventricular nucleus in senescence and senile dementia

AU - Hoogendijk, J. E.

AU - Fliers, E.

AU - Swaab, D. F.

AU - Verwer, R. W.

PY - 1985

Y1 - 1985

N2 - A recent study has shown that vasopressin (AVP) cells in the human supraoptic (SON) and paraventricular (PVN) nuclei increase in size after 60 years of age, suggesting that AVP production is increased in senescence. In the present study, the same brain material was used for the determination of nucleolar size in immunocytochemically identified AVP and oxytocin (OXT) neurons as an additional parameter for peptide production. A strong correlation was found between nucleolar size and cell size, both in AVP and OXT neurons. Nucleolar size of AVP but not of OXT neurons increased significantly in senescence. Observations in brains from patients with senile dementia of the Alzheimer type (SDAT) were commensurate with their ages. These results strongly support the hypothesis that AVP neurons in the SON and PVN are activated in old age

AB - A recent study has shown that vasopressin (AVP) cells in the human supraoptic (SON) and paraventricular (PVN) nuclei increase in size after 60 years of age, suggesting that AVP production is increased in senescence. In the present study, the same brain material was used for the determination of nucleolar size in immunocytochemically identified AVP and oxytocin (OXT) neurons as an additional parameter for peptide production. A strong correlation was found between nucleolar size and cell size, both in AVP and OXT neurons. Nucleolar size of AVP but not of OXT neurons increased significantly in senescence. Observations in brains from patients with senile dementia of the Alzheimer type (SDAT) were commensurate with their ages. These results strongly support the hypothesis that AVP neurons in the SON and PVN are activated in old age

U2 - https://doi.org/10.1016/0022-510X(85)90141-8

DO - https://doi.org/10.1016/0022-510X(85)90141-8

M3 - Article

C2 - 3897463

SN - 0022-510X

VL - 69

SP - 291

EP - 299

JO - Journal of the neurological sciences

JF - Journal of the neurological sciences

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