TY - JOUR
T1 - Acute kidney injury in patients undergoing endovascular or open repair of juxtarenal or pararenal aortic aneurysms
AU - Zlatanovic, Petar
AU - Davidovic, Lazar
AU - Mascia, Daniele
AU - Ancetti, Stefano
AU - Yeung, Kak Khee
AU - Jongkind, Vincent
AU - Vitala, Herman
AU - Venermo, Maarit
AU - Wiersema, Arno
AU - Chiesa, Roberto
AU - Gargiulo, Mauro
N1 - Publisher Copyright: © 2024 Society for Vascular Surgery
PY - 2024/6
Y1 - 2024/6
N2 - Background: The aim of this cohort study was to report the proportion of patients who develop periprocedural acute kidney injury (AKI) after endovascular repair (ER) and open surgery (OS) in patients with juxta/pararenal abdominal aortic aneurysm and to assess potential risk factors for AKI. The study also aimed to report the short- and long-term outcomes of patients with and without AKI. Methods: This was a multicenter cohort study of five European academic high-volume centers (>50 OS or 50 ER infrarenal AAA repairs, plus >15 complex AAA repairs per year). All consecutively treated patients were extracted from a prospective vascular surgical registry and the data were scrutinized retrospectively. The primary end point for this study was the development of AKI. AKI was diagnosed when there is a two-fold increase of serum creatinine or decrease of glomerular filtration rate of >50% within 1 week of AAA repair. Secondary end points included long-term mortality and end-stage renal disease (ESRD). Results: AKI occurred in 16.6% of patients in the ER group vs 30.3% in the OS group (P <.001). The 30-day mortality rate was higher among patients with AKI in both ER (15.4% vs 3.1%; P =.006) and OS (13.2% vs 5.3%; P =.001) groups. Age, chronic kidney disease, presence of significant thrombus burden in the pararenal region, >1000 mL blood loss in ER group were associated with development of AKI. Age, diabetes mellitus, chronic kidney disease, presence of significant thrombus burden in the pararenal region, and a proximal clamping time of >30 minutes in the OS group were associated with the development of AKI, whereas renal perfusion during clamping was the protective factor against AKI development. After a median follow-up of 91 months, AKI was associated with higher mortality rates in both the ER group (58.9% vs 29.7%; P <.001) and the OS group (61.5% vs 27.3%; P <.001). After the same follow-up period, AKI was associated with a higher incidence of ESRD in both the ER group (12.8% vs 3.6%; P =.009) and the OS group (9.9% vs 2.9%; P <.001). Conclusions: The current study identified important pre and postoperative factors associated with AKI after juxta/pararenal abdominal aortic aneurysm repair. Patients with postoperative AKI had significantly higher short- and long term mortality and higher incidence of ESRD than patients without AKI.
AB - Background: The aim of this cohort study was to report the proportion of patients who develop periprocedural acute kidney injury (AKI) after endovascular repair (ER) and open surgery (OS) in patients with juxta/pararenal abdominal aortic aneurysm and to assess potential risk factors for AKI. The study also aimed to report the short- and long-term outcomes of patients with and without AKI. Methods: This was a multicenter cohort study of five European academic high-volume centers (>50 OS or 50 ER infrarenal AAA repairs, plus >15 complex AAA repairs per year). All consecutively treated patients were extracted from a prospective vascular surgical registry and the data were scrutinized retrospectively. The primary end point for this study was the development of AKI. AKI was diagnosed when there is a two-fold increase of serum creatinine or decrease of glomerular filtration rate of >50% within 1 week of AAA repair. Secondary end points included long-term mortality and end-stage renal disease (ESRD). Results: AKI occurred in 16.6% of patients in the ER group vs 30.3% in the OS group (P <.001). The 30-day mortality rate was higher among patients with AKI in both ER (15.4% vs 3.1%; P =.006) and OS (13.2% vs 5.3%; P =.001) groups. Age, chronic kidney disease, presence of significant thrombus burden in the pararenal region, >1000 mL blood loss in ER group were associated with development of AKI. Age, diabetes mellitus, chronic kidney disease, presence of significant thrombus burden in the pararenal region, and a proximal clamping time of >30 minutes in the OS group were associated with the development of AKI, whereas renal perfusion during clamping was the protective factor against AKI development. After a median follow-up of 91 months, AKI was associated with higher mortality rates in both the ER group (58.9% vs 29.7%; P <.001) and the OS group (61.5% vs 27.3%; P <.001). After the same follow-up period, AKI was associated with a higher incidence of ESRD in both the ER group (12.8% vs 3.6%; P =.009) and the OS group (9.9% vs 2.9%; P <.001). Conclusions: The current study identified important pre and postoperative factors associated with AKI after juxta/pararenal abdominal aortic aneurysm repair. Patients with postoperative AKI had significantly higher short- and long term mortality and higher incidence of ESRD than patients without AKI.
KW - Abdominal aortic aneurysm (AAA)
KW - Acute kidney injury (AKI)
KW - End-stage renal disease (ESRD)
KW - Endovascular repair
KW - Juxtarenal
KW - Open surgery
KW - Pararenal
UR - http://www.scopus.com/inward/record.url?scp=85188544038&partnerID=8YFLogxK
U2 - 10.1016/j.jvs.2024.02.021
DO - 10.1016/j.jvs.2024.02.021
M3 - Article
C2 - 38395093
SN - 0741-5214
VL - 79
SP - 1347-1359.e3
JO - Journal of vascular surgery
JF - Journal of vascular surgery
IS - 6
ER -