Adaptive Brain Stimulation for Parkinson's Disease

M. Beudel

doi:https://doi.org/10.1016/B978-0-12-802452-2.00015-9

Adaptive Brain Stimulation for Parkinson's Disease

M. Beudel

Amsterdam Neuroscience - Neurodegeneration (AMC)

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

3 Citations (Scopus)

Abstract

Although deep brain stimulation (DBS) has been an established treatment for Parkinson's Disease (PD) for over 25 years, there are still limitations in terms of efficacy, side effects, and battery consumption. One of the reasons for this is that not only physiological, but also pathological neural activity, is suppressed while stimulating. For this reason, adaptive DBS (aDBS), stimulation that is only applied when pathological neural activity is present, might be of great value in treating PD. Although the first aDBS studies show an effect of adaptive stimulation on PD, there are still many questions to be answered before aDBS can be applied clinically. In the present chapter, an overview of the potential biomarkers and stimulation algorithms in adaptive stimulation in PD will be provided and a potential road-map toward clinical applicability will be sketched.

Original language	English
Title of host publication	Closed Loop Neuroscience
Publisher	Elsevier Inc.
Pages	213-222
Number of pages	10
ISBN (Electronic)	9780128026410
ISBN (Print)	9780128024522
DOIs	https://doi.org/10.1016/B978-0-12-802452-2.00015-9
Publication status	Published - 29 Sept 2016

Keywords

Adaptive stimulation
Brain-computer interface
Closed-loop
Deep brain stimulation
Neuromodulation
On-demand
Parkinson's Disease

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https://doi.org/10.1016/B978-0-12-802452-2.00015-9

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abstract = "Although deep brain stimulation (DBS) has been an established treatment for Parkinson's Disease (PD) for over 25 years, there are still limitations in terms of efficacy, side effects, and battery consumption. One of the reasons for this is that not only physiological, but also pathological neural activity, is suppressed while stimulating. For this reason, adaptive DBS (aDBS), stimulation that is only applied when pathological neural activity is present, might be of great value in treating PD. Although the first aDBS studies show an effect of adaptive stimulation on PD, there are still many questions to be answered before aDBS can be applied clinically. In the present chapter, an overview of the potential biomarkers and stimulation algorithms in adaptive stimulation in PD will be provided and a potential road-map toward clinical applicability will be sketched.",

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KW - Brain-computer interface

KW - Closed-loop

KW - Deep brain stimulation

KW - Neuromodulation

KW - On-demand

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Adaptive Brain Stimulation for Parkinson's Disease

Abstract

Keywords

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