TY - JOUR
T1 - Adaptive reciprocity of lipid and glucose metabolism in human short-term starvation
AU - Soeters, Maarten R.
AU - Soeters, Peter B.
AU - Schooneman, Marieke G.
AU - Houten, Sander M.
AU - Romijn, Johannes A.
PY - 2012
Y1 - 2012
N2 - Soeters MR, Soeters PB, Schooneman MG, Houten SM, Romijn JA. Adaptive reciprocity of lipid and glucose metabolism in human short-term starvation. Am J Physiol Endocrinol Metab 303: E1397-E1407, 2012. First published October 16, 2012; doi:10.1152/ajpendo.00397.2012.-The human organism has tools to cope with metabolic challenges like starvation that are crucial for survival. Lipolysis, lipid oxidation, ketone body synthesis, tailored endogenous glucose production and uptake, and decreased glucose oxidation serve to protect against excessive erosion of protein mass, which is the predominant supplier of carbon chains for synthesis of newly formed glucose. The starvation response shows that the adaptation to energy deficit is very effective and coordinated with different adaptations in different organs. From an evolutionary perspective, this lipid-induced effect on glucose oxidation and uptake is very strong and may therefore help to understand why insulin resistance in obesity and type 2 diabetes mellitus is difficult to treat. The importance of reciprocity in lipid and glucose metabolism during human starvation should be taken into account when studying lipid and glucose metabolism in general and in pathophysiological conditions in particular
AB - Soeters MR, Soeters PB, Schooneman MG, Houten SM, Romijn JA. Adaptive reciprocity of lipid and glucose metabolism in human short-term starvation. Am J Physiol Endocrinol Metab 303: E1397-E1407, 2012. First published October 16, 2012; doi:10.1152/ajpendo.00397.2012.-The human organism has tools to cope with metabolic challenges like starvation that are crucial for survival. Lipolysis, lipid oxidation, ketone body synthesis, tailored endogenous glucose production and uptake, and decreased glucose oxidation serve to protect against excessive erosion of protein mass, which is the predominant supplier of carbon chains for synthesis of newly formed glucose. The starvation response shows that the adaptation to energy deficit is very effective and coordinated with different adaptations in different organs. From an evolutionary perspective, this lipid-induced effect on glucose oxidation and uptake is very strong and may therefore help to understand why insulin resistance in obesity and type 2 diabetes mellitus is difficult to treat. The importance of reciprocity in lipid and glucose metabolism during human starvation should be taken into account when studying lipid and glucose metabolism in general and in pathophysiological conditions in particular
U2 - https://doi.org/10.1152/ajpendo.00397.2012
DO - https://doi.org/10.1152/ajpendo.00397.2012
M3 - Review article
C2 - 23074240
SN - 0193-1849
VL - 303
SP - E1397-E1407
JO - American journal of physiology. Endocrinology and metabolism
JF - American journal of physiology. Endocrinology and metabolism
IS - 12
ER -