TY - JOUR
T1 - Addition of glucose to an oral fat load reduces postprandial free fatty acids and prevents the postprandial increase in complement component
AU - van Oostrom, Antoine J.
AU - van Dijk, Hans
AU - Verseyden, Caroline
AU - Sniderman, Allan D.
AU - Cianflone, Katherine
AU - Rabelink, Ton J.
AU - Cabezas, Manuel Castro
PY - 2004
Y1 - 2004
N2 - Background: Elevated fasting plasma concentrations of complement component 3 (C3) are associated with elevated fasting and postprandial triacylglycerol concentrations, insulin resistance, obesity, and coronary artery disease. C3 is the central component of the complement system and the precursor of acylation-stimulating protein (ASP). Insulin and ASP are principal determinants of free fatty acid (FFA) trapping by adipose tissue. Objective: Because controversy exists concerning postprandial changes in C3 and because meal composition may influence complement activation, we studied postprandial lipemia in relation to changes in plasma C3. Design: After an overnight fast, 6 healthy men (x- ± SD age: 23 ± 2 y) underwent 4 oral liquid challenges: fat (50 g/m2 body surface), glucose (37.5 g/m 2), fat and glucose (mixed test), and water (as a control test) in a random, crossover design. Results: Plasma ASP concentrations did not change postprandially in any test. Changes in C3 concentration were observed only after the fat challenge: elevated concentrations occurred between 1 and 3 h, and a maximum increase of 11% occurred at 2 h (P = 0.05). Postprandial triacylglycerolemia did not differ significantly between the fat and mixed tests. The FFA response after the fat challenge was the highest of all the tests (P < 0.05 for all comparisons) and was accompanied by an increase in ketone bodies (maximum at 6 h); this increase did not occur after the mixed test, which suggests less hepatic FFA delivery. Conclusions: When glucose is added to an oral fat load, the postprandial FFA response is reduced, and the fat-specific increase in C3 is prevented. After ingestion of fat without glucose, the lack of insulin response may lead to C3-mediated peripheral FFA trapping, which probably serves as a backup system in case of insufficient or inefficient insulin-dependent FFA trapping. © 2004 American Society for Clinical Nutrition.
AB - Background: Elevated fasting plasma concentrations of complement component 3 (C3) are associated with elevated fasting and postprandial triacylglycerol concentrations, insulin resistance, obesity, and coronary artery disease. C3 is the central component of the complement system and the precursor of acylation-stimulating protein (ASP). Insulin and ASP are principal determinants of free fatty acid (FFA) trapping by adipose tissue. Objective: Because controversy exists concerning postprandial changes in C3 and because meal composition may influence complement activation, we studied postprandial lipemia in relation to changes in plasma C3. Design: After an overnight fast, 6 healthy men (x- ± SD age: 23 ± 2 y) underwent 4 oral liquid challenges: fat (50 g/m2 body surface), glucose (37.5 g/m 2), fat and glucose (mixed test), and water (as a control test) in a random, crossover design. Results: Plasma ASP concentrations did not change postprandially in any test. Changes in C3 concentration were observed only after the fat challenge: elevated concentrations occurred between 1 and 3 h, and a maximum increase of 11% occurred at 2 h (P = 0.05). Postprandial triacylglycerolemia did not differ significantly between the fat and mixed tests. The FFA response after the fat challenge was the highest of all the tests (P < 0.05 for all comparisons) and was accompanied by an increase in ketone bodies (maximum at 6 h); this increase did not occur after the mixed test, which suggests less hepatic FFA delivery. Conclusions: When glucose is added to an oral fat load, the postprandial FFA response is reduced, and the fat-specific increase in C3 is prevented. After ingestion of fat without glucose, the lack of insulin response may lead to C3-mediated peripheral FFA trapping, which probably serves as a backup system in case of insufficient or inefficient insulin-dependent FFA trapping. © 2004 American Society for Clinical Nutrition.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=1642341251&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/14985229
U2 - https://doi.org/10.1093/ajcn/79.3.510
DO - https://doi.org/10.1093/ajcn/79.3.510
M3 - Article
C2 - 14985229
SN - 0002-9165
VL - 79
SP - 510
EP - 515
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 3
ER -