TY - JOUR
T1 - Addressing the ethical and societal challenges posed by genome-wide association studies of behavioral and brain-related traits
AU - de Hemptinne, Matthieu C.
AU - Posthuma, Danielle
N1 - Funding Information: This work is supported by the Netherlands Organization for Scientific Research—Gravitation project ‘BRAINSCAPES: a Roadmap from Neurogenetics to Neurobiology’ (024.004.012) and the European Research Council advanced grant ‘From GWAS to Function’ (ERC-2018-ADG 834057). We thank E. Uffelmann and P. Jansen for critical reading and fruitful discussions on earlier versions of this paper, and E. Bunnik for critically reading a pre-final version from a bioethical point of view. Publisher Copyright: © 2023, Springer Nature America, Inc.
PY - 2023/6
Y1 - 2023/6
N2 - Genome-wide association studies have led to the identification of robust statistical associations of genetic variants with numerous brain-related traits, including neurological and psychiatric conditions, and psychological and behavioral measures. These results may provide insight into the biology underlying these traits and may facilitate clinically useful predictions. However, these results also carry the risk of harm, including possible negative effects of inaccurate predictions, violations of privacy, stigma and genomic discrimination, raising serious ethical and legal implications. Here, we discuss ethical concerns surrounding the results of genome-wide association studies for individuals, society and researchers. Given the success of genome-wide association studies and the increasing availability of nonclinical genomic prediction technologies, better laws and guidelines are urgently needed to regulate the storage, processing and responsible use of genetic data. Also, researchers should be aware of possible misuse of their results, and we provide guidance to help avoid such negative impacts on individuals and society.
AB - Genome-wide association studies have led to the identification of robust statistical associations of genetic variants with numerous brain-related traits, including neurological and psychiatric conditions, and psychological and behavioral measures. These results may provide insight into the biology underlying these traits and may facilitate clinically useful predictions. However, these results also carry the risk of harm, including possible negative effects of inaccurate predictions, violations of privacy, stigma and genomic discrimination, raising serious ethical and legal implications. Here, we discuss ethical concerns surrounding the results of genome-wide association studies for individuals, society and researchers. Given the success of genome-wide association studies and the increasing availability of nonclinical genomic prediction technologies, better laws and guidelines are urgently needed to regulate the storage, processing and responsible use of genetic data. Also, researchers should be aware of possible misuse of their results, and we provide guidance to help avoid such negative impacts on individuals and society.
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U2 - https://doi.org/10.1038/s41593-023-01333-4
DO - https://doi.org/10.1038/s41593-023-01333-4
M3 - Article
C2 - 37217727
SN - 1097-6256
VL - 26
SP - 932
EP - 941
JO - Nature neuroscience
JF - Nature neuroscience
IS - 6
ER -
