Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials

Nicola Coley; Tiia Ngandu; Jenni Lehtisalo; Hilkka Soininen; Bruno Vellas; Edo Richard; Miia Kivipelto; Sandrine Andrieu; Pim van Gool; Eric Moll van Charante; Cathrien Beishuizen; Susan Jongstra; Tessa van Middelaar; Lennard van Wanrooij; Marieke Hoevenaar-Blom; Mariagnese Barbera; Francesca Mangiasche; Juliette Guillemont; Yannick Meiller; Bram van de Groep; Carol Brayne; Alina Solomon; Tiina Laatikainen; Timo Strandberg; Jaakko Tuomilehto; Riitta Antikainen; Jaana Lindström; Satu Havulinna; Rainer Rauramaa; Tuomo Hänninen; Lars Bäckman; Anna Stigsdotter-Neely; Antti Jula; Markku Peltonen; Esko Levälahti; Marko Grönholm; Katri Hemiö; Sophie Guyonnet; Isabelle Carrié; Lauréane Brigitte; Catherine Faisant; Françoise Lala; Julien Delrieu; H. lène Villars; Emeline Combrouze; Carole Badufle; Audrey Zueras; Christelle Cantet; Christophe Morin; Gabor Abellan van Kan; Charlotte Dupuy; Yves Rolland; C. line Caillaud; Pierre-Jean Ousset; Bertrand Fougère; Sherry Willis; Sylvie Belleville; Brigitte Gilbert; Francine Fontaine; Jean-François Dartigues; Isabelle Marcet; Fleur Delva; Alexandra Foubert; Sandrine Cerda; null Marie-Noëlle-Cuffi; Corinne Costes; Olivier Rouaud; Patrick Manckoundia; Valérie Quipourt; Sophie Marilier; Evelyne Franon; Lawrence Bories; Marie-Laure Pader; Marie-France Basset; Bruno Lapoujade; Valérie Faure; Michael Li Yung Tong; Christine Malick-Loiseau; Evelyne Cazaban-Campistron; Françoise Desclaux; Colette Blatge; Thierry Dantoine; C. cile Laubarie-Mouret; Isabelle Saulnier; Jean-Pierre Clément; Marie-Agnès Picat; Laurence Bernard-Bourzeix; Stéphanie Willebois; Iléana Désormais; Noëlle Cardinaud; Marc Bonnefoy; Pierre Livet; Pascale Rebaudet; Claire Gédéon; Catherine Burdet; Flavien Terracol; Alain Pesce; Stéphanie Roth; Sylvie Chaillou; Sandrine Louchart; Kristelle Sudres; Nicolas Lebrun; Nadège Barro-Belaygues; Jacques Touchon; Karim Bennys; Audrey Gabelle; Aurélia Romano; Lynda Touati; C. cilia Marelli; C. cile Pays; Philippe Robert; Franck le Duff; Claire Gervais; S. bastien Gonfrier; Yannick Gasnier; Serge Bordes; Danièle Begorre; Christian Carpuat; Khaled Khales; Jean-François Lefebvre; Samira Misbah el Idrissi; Pierre Skolil; Jean-Pierre Salles; Carole Dufouil; Stéphane Lehéricy; Marie Chupin; Jean-François Mangin; Ali Bouhayia; Michèle Allard; Frédéric Ricolfi; Dominique Dubois; Marie Paule Bonceour Martel; François Cotton; Alain Bonafé; Stéphane Chanalet; Françoise Hugon; Fabrice Bonneville; Christophe Cognard; François Chollet; Pierre Payoux; Thierry Voisin; Sophie Peiffer; Anne Hitzel; Michel Zanca; Jacques Monteil; Jacques Darcourt; Laurent Molinier; H. lène Derumeaux; Nadège Costa; Christian Vincent; Bertrand Perret; Claire Vinel; Pascale Olivier-Abbal

doi:https://doi.org/10.1016/j.jalz.2019.03.005

Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials

Nicola Coley, Tiia Ngandu, Jenni Lehtisalo, Hilkka Soininen, Bruno Vellas, Edo Richard, Miia Kivipelto, Sandrine Andrieu, Pim van Gool, Eric Moll van Charante, Cathrien Beishuizen, Susan Jongstra, Tessa van Middelaar, Lennard van Wanrooij, Marieke Hoevenaar-Blom, Mariagnese Barbera, Francesca Mangiasche, Juliette Guillemont, Yannick Meiller, Bram van de GroepCarol Brayne, Alina Solomon, Tiina Laatikainen, Timo Strandberg, Jaakko Tuomilehto, Riitta Antikainen, Jaana Lindström, Satu Havulinna, Rainer Rauramaa, Tuomo Hänninen, Lars Bäckman, Anna Stigsdotter-Neely, Antti Jula, Markku Peltonen, Esko Levälahti, Marko Grönholm, Katri Hemiö, Sophie Guyonnet, Isabelle Carrié, Lauréane Brigitte, Catherine Faisant, Françoise Lala, Julien Delrieu, H. lène Villars, Emeline Combrouze, Carole Badufle, Audrey Zueras, Christelle Cantet, Christophe Morin, Gabor Abellan van Kan, Charlotte Dupuy, Yves Rolland, C. line Caillaud, Pierre-Jean Ousset, Bertrand Fougère, Sherry Willis, Sylvie Belleville, Brigitte Gilbert, Francine Fontaine, Jean-François Dartigues, Isabelle Marcet, Fleur Delva, Alexandra Foubert, Sandrine Cerda, Marie-Noëlle-Cuffi, Corinne Costes, Olivier Rouaud, Patrick Manckoundia, Valérie Quipourt, Sophie Marilier, Evelyne Franon, Lawrence Bories, Marie-Laure Pader, Marie-France Basset, Bruno Lapoujade, Valérie Faure, Michael Li Yung Tong, Christine Malick-Loiseau, Evelyne Cazaban-Campistron, Françoise Desclaux, Colette Blatge, Thierry Dantoine, C. cile Laubarie-Mouret, Isabelle Saulnier, Jean-Pierre Clément, Marie-Agnès Picat, Laurence Bernard-Bourzeix, Stéphanie Willebois, Iléana Désormais, Noëlle Cardinaud, Marc Bonnefoy, Pierre Livet, Pascale Rebaudet, Claire Gédéon, Catherine Burdet, Flavien Terracol, Alain Pesce, Stéphanie Roth, Sylvie Chaillou, Sandrine Louchart, Kristelle Sudres, Nicolas Lebrun, Nadège Barro-Belaygues, Jacques Touchon, Karim Bennys, Audrey Gabelle, Aurélia Romano, Lynda Touati, C. cilia Marelli, C. cile Pays, Philippe Robert, Franck le Duff, Claire Gervais, S. bastien Gonfrier, Yannick Gasnier, Serge Bordes, Danièle Begorre, Christian Carpuat, Khaled Khales, Jean-François Lefebvre, Samira Misbah el Idrissi, Pierre Skolil, Jean-Pierre Salles, Carole Dufouil, Stéphane Lehéricy, Marie Chupin, Jean-François Mangin, Ali Bouhayia, Michèle Allard, Frédéric Ricolfi, Dominique Dubois, Marie Paule Bonceour Martel, François Cotton, Alain Bonafé, Stéphane Chanalet, Françoise Hugon, Fabrice Bonneville, Christophe Cognard, François Chollet, Pierre Payoux, Thierry Voisin, Sophie Peiffer, Anne Hitzel, Michel Zanca, Jacques Monteil, Jacques Darcourt, Laurent Molinier, H. lène Derumeaux, Nadège Costa, Christian Vincent, Bertrand Perret, Claire Vinel, Pascale Olivier-Abbal

Research output: Contribution to journal › Article › Academic › peer-review

71 Citations (Scopus)

Abstract

Introduction: Multidomain interventions, targeting multiple risk factors simultaneously, could be effective dementia prevention strategies, but may be burdensome and not universally acceptable. Methods: We studied adherence rates and predictors in the Finnish Geriatric Intervevntion Study to Prevent Cognitive Impairment and Disability and Multidomain Alzheimer Preventive Trial prevention trials, for all intervention components (separately and simultaneously). Finnish Geriatric Intervevntion Study to Prevent Cognitive Impairment and Disability participants received a 2-year multidomain lifestyle intervention (physical training, cognitive training, nutritional counseling, and cardiovascular monitoring). Multidomain Alzheimer Preventive Trial participants received a 3-year multidomain lifestyle intervention (cognitive training, physical activity counseling, and nutritional counseling) with either an omega-3 supplement or placebo. Results: Adherence decreased with increasing intervention complexity and intensity: it was highest for cardiovascular monitoring, nutritional counseling, and the omega-3 supplement, and lowest for unsupervised computer-based cognitive training. The most consistent baseline predictors of adherence were smoking and depressive symptoms. Discussion: Reducing participant burden, while ensuring that technological tools are suitable for older individuals, maintaining face-to-face contacts, and taking into account participant characteristics may increase adherence in future trials.

Original language	English
Pages (from-to)	729-741
Journal	Alzheimer s & dementia
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/j.jalz.2019.03.005
Publication status	Published - Jun 2019

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Coley, N., Ngandu, T., Lehtisalo, J., Soininen, H., Vellas, B., Richard, E., Kivipelto, M., Andrieu, S., van Gool, P., van Charante, E. M., Beishuizen, C., Jongstra, S., van Middelaar, T., van Wanrooij, L., Hoevenaar-Blom, M., Barbera, M., Mangiasche, F., Guillemont, J., Meiller, Y., ... Olivier-Abbal, P. (2019). Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials. Alzheimer s & dementia, 15(6), 729-741. https://doi.org/10.1016/j.jalz.2019.03.005

@article{791d39d1ac954f2ba877c75c0395b6e1,

title = "Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials",

abstract = "Introduction: Multidomain interventions, targeting multiple risk factors simultaneously, could be effective dementia prevention strategies, but may be burdensome and not universally acceptable. Methods: We studied adherence rates and predictors in the Finnish Geriatric Intervevntion Study to Prevent Cognitive Impairment and Disability and Multidomain Alzheimer Preventive Trial prevention trials, for all intervention components (separately and simultaneously). Finnish Geriatric Intervevntion Study to Prevent Cognitive Impairment and Disability participants received a 2-year multidomain lifestyle intervention (physical training, cognitive training, nutritional counseling, and cardiovascular monitoring). Multidomain Alzheimer Preventive Trial participants received a 3-year multidomain lifestyle intervention (cognitive training, physical activity counseling, and nutritional counseling) with either an omega-3 supplement or placebo. Results: Adherence decreased with increasing intervention complexity and intensity: it was highest for cardiovascular monitoring, nutritional counseling, and the omega-3 supplement, and lowest for unsupervised computer-based cognitive training. The most consistent baseline predictors of adherence were smoking and depressive symptoms. Discussion: Reducing participant burden, while ensuring that technological tools are suitable for older individuals, maintaining face-to-face contacts, and taking into account participant characteristics may increase adherence in future trials.",

author = "Nicola Coley and Tiia Ngandu and Jenni Lehtisalo and Hilkka Soininen and Bruno Vellas and Edo Richard and Miia Kivipelto and Sandrine Andrieu and {van Gool}, Pim and {van Charante}, {Eric Moll} and Cathrien Beishuizen and Susan Jongstra and {van Middelaar}, Tessa and {van Wanrooij}, Lennard and Marieke Hoevenaar-Blom and Mariagnese Barbera and Francesca Mangiasche and Juliette Guillemont and Yannick Meiller and {van de Groep}, Bram and Carol Brayne and Alina Solomon and Tiina Laatikainen and Timo Strandberg and Jaakko Tuomilehto and Riitta Antikainen and Jaana Lindstr{\"o}m and Satu Havulinna and Rainer Rauramaa and Tuomo H{\"a}nninen and Lars B{\"a}ckman and Anna Stigsdotter-Neely and Antti Jula and Markku Peltonen and Esko Lev{\"a}lahti and Marko Gr{\"o}nholm and Katri Hemi{\"o} and Sophie Guyonnet and Isabelle Carri{\'e} and Laur{\'e}ane Brigitte and Catherine Faisant and Fran{\c c}oise Lala and Julien Delrieu and Villars, {H. l{\`e}ne} and Emeline Combrouze and Carole Badufle and Audrey Zueras and Christelle Cantet and Christophe Morin and {van Kan}, {Gabor Abellan} and Charlotte Dupuy and Yves Rolland and Caillaud, {C. line} and Pierre-Jean Ousset and Bertrand Foug{\`e}re and Sherry Willis and Sylvie Belleville and Brigitte Gilbert and Francine Fontaine and Jean-Fran{\c c}ois Dartigues and Isabelle Marcet and Fleur Delva and Alexandra Foubert and Sandrine Cerda and Marie-No{\"e}lle-Cuffi and Corinne Costes and Olivier Rouaud and Patrick Manckoundia and Val{\'e}rie Quipourt and Sophie Marilier and Evelyne Franon and Lawrence Bories and Marie-Laure Pader and Marie-France Basset and Bruno Lapoujade and Val{\'e}rie Faure and {Yung Tong}, {Michael Li} and Christine Malick-Loiseau and Evelyne Cazaban-Campistron and Fran{\c c}oise Desclaux and Colette Blatge and Thierry Dantoine and Laubarie-Mouret, {C. cile} and Isabelle Saulnier and Jean-Pierre Cl{\'e}ment and Marie-Agn{\`e}s Picat and Laurence Bernard-Bourzeix and St{\'e}phanie Willebois and Il{\'e}ana D{\'e}sormais and No{\"e}lle Cardinaud and Marc Bonnefoy and Pierre Livet and Pascale Rebaudet and Claire G{\'e}d{\'e}on and Catherine Burdet and Flavien Terracol and Alain Pesce and St{\'e}phanie Roth and Sylvie Chaillou and Sandrine Louchart and Kristelle Sudres and Nicolas Lebrun and Nad{\`e}ge Barro-Belaygues and Jacques Touchon and Karim Bennys and Audrey Gabelle and Aur{\'e}lia Romano and Lynda Touati and Marelli, {C. cilia} and Pays, {C. cile} and Philippe Robert and {le Duff}, Franck and Claire Gervais and Gonfrier, {S. bastien} and Yannick Gasnier and Serge Bordes and Dani{\`e}le Begorre and Christian Carpuat and Khaled Khales and Jean-Fran{\c c}ois Lefebvre and {el Idrissi}, {Samira Misbah} and Pierre Skolil and Jean-Pierre Salles and Carole Dufouil and St{\'e}phane Leh{\'e}ricy and Marie Chupin and Jean-Fran{\c c}ois Mangin and Ali Bouhayia and Mich{\`e}le Allard and Fr{\'e}d{\'e}ric Ricolfi and Dominique Dubois and {Bonceour Martel}, {Marie Paule} and Fran{\c c}ois Cotton and Alain Bonaf{\'e} and St{\'e}phane Chanalet and Fran{\c c}oise Hugon and Fabrice Bonneville and Christophe Cognard and Fran{\c c}ois Chollet and Pierre Payoux and Thierry Voisin and Sophie Peiffer and Anne Hitzel and Michel Zanca and Jacques Monteil and Jacques Darcourt and Laurent Molinier and Derumeaux, {H. l{\`e}ne} and Nad{\`e}ge Costa and Christian Vincent and Bertrand Perret and Claire Vinel and Pascale Olivier-Abbal",

year = "2019",

month = jun,

doi = "https://doi.org/10.1016/j.jalz.2019.03.005",

language = "English",

volume = "15",

pages = "729--741",

journal = "Alzheimer s & dementia",

issn = "1552-5260",

publisher = "Elsevier Inc.",

number = "6",

}

Coley, N, Ngandu, T, Lehtisalo, J, Soininen, H, Vellas, B, Richard, E, Kivipelto, M, Andrieu, S, van Gool, P, van Charante, EM, Beishuizen, C, Jongstra, S, van Middelaar, T, van Wanrooij, L, Hoevenaar-Blom, M, Barbera, M, Mangiasche, F, Guillemont, J, Meiller, Y, van de Groep, B, Brayne, C, Solomon, A, Laatikainen, T, Strandberg, T, Tuomilehto, J, Antikainen, R, Lindström, J, Havulinna, S, Rauramaa, R, Hänninen, T, Bäckman, L, Stigsdotter-Neely, A, Jula, A, Peltonen, M, Levälahti, E, Grönholm, M, Hemiö, K, Guyonnet, S, Carrié, I, Brigitte, L, Faisant, C, Lala, F, Delrieu, J, Villars, HL, Combrouze, E, Badufle, C, Zueras, A, Cantet, C, Morin, C, van Kan, GA, Dupuy, C, Rolland, Y, Caillaud, CL, Ousset, P-J, Fougère, B, Willis, S, Belleville, S, Gilbert, B, Fontaine, F, Dartigues, J-F, Marcet, I, Delva, F, Foubert, A, Cerda, S, Marie-Noëlle-Cuffi, Costes, C, Rouaud, O, Manckoundia, P, Quipourt, V, Marilier, S, Franon, E, Bories, L, Pader, M-L, Basset, M-F, Lapoujade, B, Faure, V, Yung Tong, ML, Malick-Loiseau, C, Cazaban-Campistron, E, Desclaux, F, Blatge, C, Dantoine, T, Laubarie-Mouret, CC, Saulnier, I, Clément, J-P, Picat, M-A, Bernard-Bourzeix, L, Willebois, S, Désormais, I, Cardinaud, N, Bonnefoy, M, Livet, P, Rebaudet, P, Gédéon, C, Burdet, C, Terracol, F, Pesce, A, Roth, S, Chaillou, S, Louchart, S, Sudres, K, Lebrun, N, Barro-Belaygues, N, Touchon, J, Bennys, K, Gabelle, A, Romano, A, Touati, L, Marelli, CC, Pays, CC, Robert, P, le Duff, F, Gervais, C, Gonfrier, SB, Gasnier, Y, Bordes, S, Begorre, D, Carpuat, C, Khales, K, Lefebvre, J-F, el Idrissi, SM, Skolil, P, Salles, J-P, Dufouil, C, Lehéricy, S, Chupin, M, Mangin, J-F, Bouhayia, A, Allard, M, Ricolfi, F, Dubois, D, Bonceour Martel, MP, Cotton, F, Bonafé, A, Chanalet, S, Hugon, F, Bonneville, F, Cognard, C, Chollet, F, Payoux, P, Voisin, T, Peiffer, S, Hitzel, A, Zanca, M, Monteil, J, Darcourt, J, Molinier, L, Derumeaux, HL, Costa, N, Vincent, C, Perret, B, Vinel, C & Olivier-Abbal, P 2019, 'Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials', Alzheimer s & dementia, vol. 15, no. 6, pp. 729-741. https://doi.org/10.1016/j.jalz.2019.03.005

TY - JOUR

T1 - Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials

AU - Coley, Nicola

AU - Ngandu, Tiia

AU - Lehtisalo, Jenni

AU - Soininen, Hilkka

AU - Vellas, Bruno

AU - Richard, Edo

AU - Kivipelto, Miia

AU - Andrieu, Sandrine

AU - van Gool, Pim

AU - van Charante, Eric Moll

AU - Beishuizen, Cathrien

AU - Jongstra, Susan

AU - van Middelaar, Tessa

AU - van Wanrooij, Lennard

AU - Hoevenaar-Blom, Marieke

AU - Barbera, Mariagnese

AU - Mangiasche, Francesca

AU - Guillemont, Juliette

AU - Meiller, Yannick

AU - van de Groep, Bram

AU - Brayne, Carol

AU - Solomon, Alina

AU - Laatikainen, Tiina

AU - Strandberg, Timo

AU - Tuomilehto, Jaakko

AU - Antikainen, Riitta

AU - Lindström, Jaana

AU - Havulinna, Satu

AU - Rauramaa, Rainer

AU - Hänninen, Tuomo

AU - Bäckman, Lars

AU - Stigsdotter-Neely, Anna

AU - Jula, Antti

AU - Peltonen, Markku

AU - Levälahti, Esko

AU - Grönholm, Marko

AU - Hemiö, Katri

AU - Guyonnet, Sophie

AU - Carrié, Isabelle

AU - Brigitte, Lauréane

AU - Faisant, Catherine

AU - Lala, Françoise

AU - Delrieu, Julien

AU - Villars, H. lène

AU - Combrouze, Emeline

AU - Badufle, Carole

AU - Zueras, Audrey

AU - Cantet, Christelle

AU - Morin, Christophe

AU - van Kan, Gabor Abellan

AU - Dupuy, Charlotte

AU - Rolland, Yves

AU - Caillaud, C. line

AU - Ousset, Pierre-Jean

AU - Fougère, Bertrand

AU - Willis, Sherry

AU - Belleville, Sylvie

AU - Gilbert, Brigitte

AU - Fontaine, Francine

AU - Dartigues, Jean-François

AU - Marcet, Isabelle

AU - Delva, Fleur

AU - Foubert, Alexandra

AU - Cerda, Sandrine

AU - Marie-Noëlle-Cuffi, null

AU - Costes, Corinne

AU - Rouaud, Olivier

AU - Manckoundia, Patrick

AU - Quipourt, Valérie

AU - Marilier, Sophie

AU - Franon, Evelyne

AU - Bories, Lawrence

AU - Pader, Marie-Laure

AU - Basset, Marie-France

AU - Lapoujade, Bruno

AU - Faure, Valérie

AU - Yung Tong, Michael Li

AU - Malick-Loiseau, Christine

AU - Cazaban-Campistron, Evelyne

AU - Desclaux, Françoise

AU - Blatge, Colette

AU - Dantoine, Thierry

AU - Laubarie-Mouret, C. cile

AU - Saulnier, Isabelle

AU - Clément, Jean-Pierre

AU - Picat, Marie-Agnès

AU - Bernard-Bourzeix, Laurence

AU - Willebois, Stéphanie

AU - Désormais, Iléana

AU - Cardinaud, Noëlle

AU - Bonnefoy, Marc

AU - Livet, Pierre

AU - Rebaudet, Pascale

AU - Gédéon, Claire

AU - Burdet, Catherine

AU - Terracol, Flavien

AU - Pesce, Alain

AU - Roth, Stéphanie

AU - Chaillou, Sylvie

AU - Louchart, Sandrine

AU - Sudres, Kristelle

AU - Lebrun, Nicolas

AU - Barro-Belaygues, Nadège

AU - Touchon, Jacques

AU - Bennys, Karim

AU - Gabelle, Audrey

AU - Romano, Aurélia

AU - Touati, Lynda

AU - Marelli, C. cilia

AU - Pays, C. cile

AU - Robert, Philippe

AU - le Duff, Franck

AU - Gervais, Claire

AU - Gonfrier, S. bastien

AU - Gasnier, Yannick

AU - Bordes, Serge

AU - Begorre, Danièle

AU - Carpuat, Christian

AU - Khales, Khaled

AU - Lefebvre, Jean-François

AU - el Idrissi, Samira Misbah

AU - Skolil, Pierre

AU - Salles, Jean-Pierre

AU - Dufouil, Carole

AU - Lehéricy, Stéphane

AU - Chupin, Marie

AU - Mangin, Jean-François

AU - Bouhayia, Ali

AU - Allard, Michèle

AU - Ricolfi, Frédéric

AU - Dubois, Dominique

AU - Bonceour Martel, Marie Paule

AU - Cotton, François

AU - Bonafé, Alain

AU - Chanalet, Stéphane

AU - Hugon, Françoise

AU - Bonneville, Fabrice

AU - Cognard, Christophe

AU - Chollet, François

AU - Payoux, Pierre

AU - Voisin, Thierry

AU - Peiffer, Sophie

AU - Hitzel, Anne

AU - Zanca, Michel

AU - Monteil, Jacques

AU - Darcourt, Jacques

AU - Molinier, Laurent

AU - Derumeaux, H. lène

AU - Costa, Nadège

AU - Vincent, Christian

AU - Perret, Bertrand

AU - Vinel, Claire

AU - Olivier-Abbal, Pascale

PY - 2019/6

Y1 - 2019/6

N2 - Introduction: Multidomain interventions, targeting multiple risk factors simultaneously, could be effective dementia prevention strategies, but may be burdensome and not universally acceptable. Methods: We studied adherence rates and predictors in the Finnish Geriatric Intervevntion Study to Prevent Cognitive Impairment and Disability and Multidomain Alzheimer Preventive Trial prevention trials, for all intervention components (separately and simultaneously). Finnish Geriatric Intervevntion Study to Prevent Cognitive Impairment and Disability participants received a 2-year multidomain lifestyle intervention (physical training, cognitive training, nutritional counseling, and cardiovascular monitoring). Multidomain Alzheimer Preventive Trial participants received a 3-year multidomain lifestyle intervention (cognitive training, physical activity counseling, and nutritional counseling) with either an omega-3 supplement or placebo. Results: Adherence decreased with increasing intervention complexity and intensity: it was highest for cardiovascular monitoring, nutritional counseling, and the omega-3 supplement, and lowest for unsupervised computer-based cognitive training. The most consistent baseline predictors of adherence were smoking and depressive symptoms. Discussion: Reducing participant burden, while ensuring that technological tools are suitable for older individuals, maintaining face-to-face contacts, and taking into account participant characteristics may increase adherence in future trials.

AB - Introduction: Multidomain interventions, targeting multiple risk factors simultaneously, could be effective dementia prevention strategies, but may be burdensome and not universally acceptable. Methods: We studied adherence rates and predictors in the Finnish Geriatric Intervevntion Study to Prevent Cognitive Impairment and Disability and Multidomain Alzheimer Preventive Trial prevention trials, for all intervention components (separately and simultaneously). Finnish Geriatric Intervevntion Study to Prevent Cognitive Impairment and Disability participants received a 2-year multidomain lifestyle intervention (physical training, cognitive training, nutritional counseling, and cardiovascular monitoring). Multidomain Alzheimer Preventive Trial participants received a 3-year multidomain lifestyle intervention (cognitive training, physical activity counseling, and nutritional counseling) with either an omega-3 supplement or placebo. Results: Adherence decreased with increasing intervention complexity and intensity: it was highest for cardiovascular monitoring, nutritional counseling, and the omega-3 supplement, and lowest for unsupervised computer-based cognitive training. The most consistent baseline predictors of adherence were smoking and depressive symptoms. Discussion: Reducing participant burden, while ensuring that technological tools are suitable for older individuals, maintaining face-to-face contacts, and taking into account participant characteristics may increase adherence in future trials.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85065163640&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/31047857

U2 - https://doi.org/10.1016/j.jalz.2019.03.005

DO - https://doi.org/10.1016/j.jalz.2019.03.005

M3 - Article

C2 - 31047857

SN - 1552-5260

VL - 15

SP - 729

EP - 741

JO - Alzheimer s & dementia

JF - Alzheimer s & dementia

IS - 6

ER -

Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials

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