TY - JOUR
T1 - Adjunctive quetiapine for serotonin reuptake inhibitor-resistant obsessive-compulsive disorder: a meta-analysis of randomized controlled treatment trials
AU - Fineberg, Naomi A.
AU - Stein, Dan J.
AU - Premkumar, Preethi
AU - Carey, Paul
AU - Sivakumaran, Thanusha
AU - Vythilingum, Bavanisha
AU - Seedat, Soraya
AU - Westenberg, Herman
AU - Denys, Damiaan
PY - 2006
Y1 - 2006
N2 - Small studies have shown positive effects from adding a variety of antipsychotic agents in patients with obsessive-compulsive disorder who are unresponsive to treatment with serotonin reuptake inhibitors. The evidence, however, is contradictory. This paper reports a meta-analysis of existing double-blind randomized placebo-controlled studies looking at the addition of the second-generation antipsychotic quetiapine in such cases. Three studies fulfilled the inclusion criteria. Altogether 102 individuals were subjected to analysis using Review Manager (4.2.7). The results showed evidence of efficacy for adjunctive quetiapine ( <400 mg/day) on the primary efficacy criterion, measured as changes from baseline in total Yale-Brown Obsessive Compulsive Scale scores (P=0.008), the clinical significance of which was limited by between-study heterogeneity. The mechanism underlying the effect may involve serotonin and/or dopamine neurotransmission
AB - Small studies have shown positive effects from adding a variety of antipsychotic agents in patients with obsessive-compulsive disorder who are unresponsive to treatment with serotonin reuptake inhibitors. The evidence, however, is contradictory. This paper reports a meta-analysis of existing double-blind randomized placebo-controlled studies looking at the addition of the second-generation antipsychotic quetiapine in such cases. Three studies fulfilled the inclusion criteria. Altogether 102 individuals were subjected to analysis using Review Manager (4.2.7). The results showed evidence of efficacy for adjunctive quetiapine ( <400 mg/day) on the primary efficacy criterion, measured as changes from baseline in total Yale-Brown Obsessive Compulsive Scale scores (P=0.008), the clinical significance of which was limited by between-study heterogeneity. The mechanism underlying the effect may involve serotonin and/or dopamine neurotransmission
U2 - https://doi.org/10.1097/01.yic.0000215083.57801.11
DO - https://doi.org/10.1097/01.yic.0000215083.57801.11
M3 - Article
C2 - 17012980
SN - 0268-1315
VL - 21
SP - 337
EP - 343
JO - International Clinical Psychopharmacology
JF - International Clinical Psychopharmacology
IS - 6
ER -